TESTOSTERONE REPLACEMENT THERAPY: HOW TO MAKE SENSE OF CONFLICTING ADVICE: Edited by Peter N. SchlegelTestosterone therapy improves well being and psychological healthAkerman, Jasona; Kovac, Jason R.b; Lipshultz, Larry I.cAuthor Information aDepartment of Urology, McMaster University, Hamilton, Ontario, Canada bMen's Health Center, Urology of Indiana, Indianapolis, Indiana cScott Department of Urology, Baylor College of Medicine, Houston, Texas, USA Correspondence to Larry I. Lipshultz, MD, Scott Department of Urology, Baylor College of Medicine, 6624 Fannin Street, Suite 1700, Houston, TX 77030, USA. E-mail: [email protected] Current Opinion in Urology: November 2017 - Volume 27 - Issue 6 - p 519-524 doi: 10.1097/MOU.0000000000000440 Buy Metrics Abstract Purpose of review To ascertain whether testosterone therapy (TTh) improves psychological health and a sense of overall well being in a number of clinical domains. Recent findings Recent work suggests small but durable and replicable improvements in the components of male health and well being. Summary Symptomatic hypogonadism is frequently associated with decreased libido and fatigue that contributes to lowered overall quality-of-life and worsening psychological health. This manuscript will review the evidence behind the generalized benefits of TTh on overall male health as well as on depression and cognitive function in particular. Influence of TTh on body composition and its relationship to cardiovascular disease are also discussed in this overall context. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.