TESTOSTERONE REPLACEMENT THERAPY: HOW TO MAKE SENSE OF CONFLICTING ADVICE: Edited by Peter N. SchlegelTestosterone and sexual functionFugh-Berman, Adrianea; Scialli, Anthony R.bAuthor Information aDepartment of Pharmacology and Physiology, Georgetown University Medical Center bDepartment of Obstetrics and Gynecology, George Washington University School of Medicine, and Scialli Consulting LLC, Washington, District of Columbia, USA Correspondence to Adriane Fugh-Berman, MD, Professor, Department of Pharmacology and Physiology, Georgetown University Medical Center, 3900 Reservoir Rd. N.W. Med-Dent SE 402, Washington, DC 20057, USA. Tel: +1 202 687 7845; e-mail: [email protected] Current Opinion in Urology: November 2017 - Volume 27 - Issue 6 - p 516-518 doi: 10.1097/MOU.0000000000000438 Buy Metrics Abstract Purpose of review Testosterone therapy has been advocated in the treatment of symptoms that may represent normal aging. We briefly review randomized clinical trials on the effects of testosterone therapy on sexual function. Recent findings About half of clinical trials showed no benefit of testosterone therapy on any aspect of sexual function. In those studies showing a benefit on some aspect of sexual function, most sexual function domains were not improved. Testosterone therapy has been disappointing in the treatment of erectile dysfunction. Potential risks of therapy include an increase in thromboembolic and other cardiovascular diseases. Summary The limited and inconsistent benefits of testosterone therapy for sexual function argue against use of this therapy in aging men, including those with ‘low testosterone’. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.