BIOMARKERS, PHENOTYPING, GENETICS AND PREDICTIVE MODELS FOR UROLOGIC CARE: Edited by Matthew Cooperberg and Thorsten SchlommGenomic testing for localized prostate cancer where do we go from here?Loeb, Stacya,b; Ross, Ashley E.a,b Author Information aDepartment of Urology and Population Health, New York University, and the Manhattan VA Medical Center, New York, New York bBrady Urological Institute, Johns Hopkins Medical Institutes, Baltimore, Maryland, USA Correspondence to Stacy Loeb, MD, MSc, Department of Urology and Population Health, New York University, 550 1st Ave, VZ30 (6th floor, #612), New York, NY 10016, USA. Tel: +1 646 825 6358; fax: +1 212 263 4549; e-mail: [email protected] Current Opinion in Urology: September 2017 - Volume 27 - Issue 5 - p 495-499 doi: 10.1097/MOU.0000000000000419 Buy Metrics Abstract Purpose of review The goal of this article is to discuss current genomic testing options in localized prostate cancer. Recent findings There are multiple genomic tests currently available for men with localized prostate cancer. Prolaris, OncotypeDx, and Decipher can all be tested using biopsy tissue. Prolaris and Decipher are also available for men undergoing radical prostatectomy to predict subsequent disease progression. Summary The Prolaris cell cycle progression score measured on biopsy predicts the risk of prostate cancer death in 10 years with conservative management, whereas, the primary endpoint for the OncotypeDx genomic prostate score is the risk of adverse disease at radical prostatectomy. Decipher measures genome-wide RNA expression, and its Genomic Classifier signature was initially designed to predict the risk of metastasis for men with adverse disease at radical prostatectomy, and more recently, a biopsy version was released. Recently, Decipher signatures predicting prostate cancer cell lineage and postoperative radiation sensitivity have also been described. Any of these tests can be used by men with localized prostate cancer to provide additional prognostic risk stratification to aid in treatment decisions. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.