SPECIAL COMMENTARIESThe effect of COVID-19 on liver transplantation: impact, practice patterns, therapeutics, and next stepsHutchison, Alan L.a; Pillai, AnjanabAuthor Information aDepartment of Internal Medicine bDepartment of Internal Medicine, Center for Liver Diseases, University of Chicago Medicine, Chicago, IL, USA Correspondence to Anjana Pillai, MD, Center for Liver Diseases, The University of Chicago Medicine, 5841 S. Maryland Ave, MC 7120, Chicago, IL 60637, USA. Tel: +1 773 795 4985; e-mail: [email protected] Current Opinion in Organ Transplantation: June 2021 - Volume 26 - Issue 3 - p 339-345 doi: 10.1097/MOT.0000000000000883 Buy Metrics Abstract Purpose of review To assess the impact of coronavirus disease 2019 (COVID-19) and the pandemic on liver transplant candidates, recipients, and donors, and review guidelines and recommendations for integrating COVID-19 therapies into current practice. Recent findings COVID-19 has high morbidity and mortality for transplant candidates; interestingly, posttransplant comorbidities play a larger role than immunosuppression status. COVID-19 therapies and vaccinations are well tolerated in pre and postliver transplant patients with few exceptions, although further research is needed regarding effectiveness in this patient population. Provider practice patterns should evolve to minimize contagion during the current pandemic and prepare for an increase in liver disease due to after-shocks of missed diagnosis and progression of liver disease. Summary COVID-19 has spurred new research and technologies to ensure the safety of liver transplant candidates, recipients, and donors, and most COVID-19 therapies are safe in this patient population. Further work needs to be done regarding the use of COVID-19 positive organs and the efficacy of vaccines in the transplant population. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.