LIVER TRANSPLANTATION: Edited by Srinath ChinnakotlaEx-situ liver preservation with machine preservationLembach Jahnsen, Hannsa; Mergental, Hyneka,b,c; Perera, M. Thamara P.R.a; Mirza, Darius F.a,b,cAuthor Information aLiver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT), Birmingham bNational Institute for Health Research (NIHR), Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust cCentre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, United Kingdom Correspondence to Professor Darius F. Mirza, Professor of HPB and Transplant Surgery, Liver Units, Queen Elizabeth Hospital and Birmingham Children's Hospital, Birmingham, United Kingdom. Tel: +44 121 371 4644; e-mail: [email protected] Current Opinion in Organ Transplantation: April 2021 - Volume 26 - Issue 2 - p 121-132 doi: 10.1097/MOT.0000000000000864 Buy Metrics Abstract Purpose of review To summarize key studies in liver preservation published over the last 3 years and evaluate benefits and limitations of the different perfusion techniques. Selected experimental applications that may be translated to the clinical use will be also discussed. Recent findings Normothermic machine perfusion (NMP) has transitioned into clinical practice. Viability assessment is a reliable tool for clinical decision-making, and safety of the back-to-base approach has facilitated adoption of the technology. Data supporting well tolerated use of declined livers after NMP and new protocols selecting complex recipients aim to improve access to suitable organs. Hypothermic machine perfusion (HMP) is showing promising clinical results by decreasing biliary complications in recipients’ receiving organs donated after circulatory death (DCD) and improving early graft function in extended criteria organs. Long-term data of HMP on DCD livers shows improved graft survival over standard SCS. Novel approaches utilizing sequential HMP--NMP or ischaemia-free preservation aim to improve outcomes of extended criteria organs. Summary Machine perfusion for organ transplantation has become an established technique but the field is rapidly evolving. Ongoing research focuses on evaluation of the intervention efficacy and finding optimal indications to use each perfusion strategy according to graft type and clinical scenario. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.