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Screening of donors and recipients for infections prior to solid organ transplantation

Nanayakkara, Deepa D.; Schaenman, Joanna

Current Opinion in Organ Transplantation: August 2019 - Volume 24 - Issue 4 - p 456–464
doi: 10.1097/MOT.0000000000000671
INFECTIOUS DISEASES: Edited by Emily Blodget
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Purpose of review This review is a brief overview of current guidelines on screening donors and candidates for bacterial, fungal, parasitic and viral infections prior to solid organ transplantation. The pretransplant period is an important time to evaluate infection exposure risk based on social history as well as to offer vaccinations.

Recent findings One of the major changes in the past few years has been increased utilization of increased Public Health Service risk, HIV positive, and hepatitis C-positive donors. There has also been increased attention to donor and recipient risks for geographically associated infections, such as endemic fungal infections and flaviviruses.

Summary Screening for donors and candidates prior to organ transplantation can identify and address infection risks. Diagnosing infections in a timely manner can help guide treatment and additional testing. Use of necessary prophylactic treatment in organ recipients can prevent reactivation of latent infections and improve posttransplant outcomes.

Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA

Correspondence to Deepa D. Nanayakkara, MD, Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, CHS 37-121, Los Angeles, CA 90095, USA. Tel: +1 310 825 7225; e-mail: DNanayakkara@mednet.ucla.edu

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