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Bioengineering the innate vasculature of complex organs

what have we learned so far

Wijesekara, Piyumia; Ng, Wai Hoea,b; Feng, Minruia; Ren, Xia,c

Current Opinion in Organ Transplantation: December 2018 - Volume 23 - Issue 6 - p 657–663
doi: 10.1097/MOT.0000000000000577
ORGANOGENESIS: Edited by Giuseppe Orlando

Purpose of review Engineering vasculature that meets an organ's specific physiology and function is a fundamental step in organ bioengineering. In this article, we review approaches for engineering functional vasculature for organ bioengineering, with an emphasis on the engineering of organ-specific endothelium and vasculature.

Recent findings Recent advances in hydrogel-based engineering of vascularized organ bud enable vascular regeneration in self-assembled cellular niche containing parenchymal and stromal cells. The emerging technology of whole-organ decellularization provides scaffold materials that serve as extracellular niche guiding vascular regeneration to recapitulate native organ's vascular anatomy. Increasing morphological and molecular evidences suggest endothelial heterogeneity across different organs and across different vascular compartments within an organ. Deriving organ-specific endothelium from pluripotent stem cells has been shown to be possible by combining endothelial induction with parenchymal differentiation.

Summary Engineering organ-specific vasculature requires the combination of organ-specific endothelium with its unique cellular and extracellular niches. Future investigations are required to further delineate the mechanisms for induction and maintenance of organ-specific vascular phenotypes, and how to incorporate these mechanisms to engineering organ-specific vasculature.

aDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA

bAdvanced Medical and Dental Institute, Universiti Sains Malaysia, Penang, Malaysia

cMcGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Correspondence to Xi Ren, PhD, Carnegie Mellon University, Scott Hall 4N111, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA. Tel: +1 412 268 7485; e-mail: xir@andrew.cmu.edu

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