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Apoptotic cell-based therapies for promoting transplantation tolerance

Dangi, Anila,b; Yu, Shuangjinb; Luo, Xunronga,b,c

Current Opinion in Organ Transplantation: October 2018 - Volume 23 - Issue 5 - p 552–558
doi: 10.1097/MOT.0000000000000562
REGULATORY IMMUNE CELLS IN ORGAN TRANSPLANTATION AND THEIR THERAPEUTIC APPLICATION: Edited by Angus W. Thomson
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Purpose of review This article is aimed to provide readers with an updated review on the applicability, efficacy, and challenges of employing donor apoptotic cell-based therapies to promote transplantation tolerance in various experimental and clinical settings.

Recent findings Recently, donor apoptotic cell-based therapies have been employed in various models of cell (including pancreatic islets and bone marrow hematopoietic stem cells) and solid organ (heart and kidney) transplantation to promote donor-specific tolerance. Published data, thus far, have revealed a high potential of this approach in inducing robust transplantation tolerance. Recent clinical trials have also underscored the safety and potential efficacy of this approach in alleviating graft-versus-host disease (GVHD) in bone marrow transplantation (BMT). Host factors including prior allo-sensitization and opportunistic infections pose major obstacles in establishing transplantation tolerance employing this strategy. However, emerging data provide strategies for overcoming such obstacles in these clinically relevant settings.

Summary Donor apoptotic cell therapy is an emerging strategy in promoting transplantation tolerance, with recent data emphasizing its efficacy and applicability for transplantation tolerance in the clinic.

aCenter for Kidney Research and Therapeutics, Feinberg Cardiovascular Research Institute

bDivision of Nephrology and Hypertension, Department of Medicine

cComprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Ilinois, USA

Correspondence to Xunrong Luo, Center for Kidney Research and Therapeutics, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Searle Building 10-515, Chicago, IL 60611, USA. Tel: +1 312 908 8147; fax: +1 312 503 0622; e-mail: xunrongluo@northwestern.edu

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