ORGAN PRESERVATION AND PROCUREMENT: Edited by Erik B. FingerOrgan preservation solutions linking pharmacology to survival for the donor organ pathwayFuller, Barry; Froghi, Farid; Davidson, BrianAuthor Information Division of Surgery & Interventional Sciences, University College London (UCL), Royal Free Hospital, Pond Street, London, UK Correspondence to Barry Fuller, Division of Surgery & Interventional Sciences, University College London (UCL), 9th Floor Royal Free Hospital, Pond Street, London NW3 2QG, UK. E-mail: [email protected] Current Opinion in Organ Transplantation: June 2018 - Volume 23 - Issue 3 - p 361-368 doi: 10.1097/MOT.0000000000000525 Buy Metrics Abstract Purpose of review To provide an understanding of the scientific principles, which underpinned the development of organ preservation solutions, and to bring into context new strategies and challenges for solution development against the background of changing preservation technologies and expanded criteria donor access. Recent findings Improvements in organ preservation solutions continue to be made with new pharmacological approaches. New solutions have been developed for dynamic perfusion preservation and are now in clinical application. Principles defining organ preservation solution pharmacology are being applied for cold chain logistics in tissue engineering and regenerative medicine. Summary Organ preservation solutions support the donor organ pathway. The solution compositions allow additives and pharmacological agents to be delivered direct to the target organ to mitigate preservation injury. Changing preservation strategies provide further challenges and opportunities to improve organ preservation solutions. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.