MACHINE PERFUSION OF ORGANS: Edited by Peter FriendNormothermic machine perfusion of the kidneyWeissenbacher, Annemariea , b; Hunter, JamesaAuthor Information aOxford Transplant Centre, Nuffield Department of Surgical Sciences, Churchill Hospital, Oxford, United Kingdom bDepartment for Visceral, Thoracic and Transplant Surgery, Innsbruck Medical University, Innsbruck, Austria Correspondence to Dr Annemarie Weissenbacher, Oxford Transplant Centre, Nuffield Department of Surgical Sciences, Churchill Hospital, Old Road, Oxford OX3 7LE, United Kingdom. E-mail: [email protected] Current Opinion in Organ Transplantation: December 2017 - Volume 22 - Issue 6 - p 571-576 doi: 10.1097/MOT.0000000000000470 Buy Metrics Abstract Purpose of review Normothermic machine perfusion (NMP) is a preservation method that is generating increasing interest. The aim of this review is to summarise the current status of NMP in regards of kidney viability assessment, reducing organ damage and improving transplant logistics. Recent findings The results of recent large animal experiments and clinical trials show that continuous prolonged normothermic ex-vivo kidney perfusion appears better than a brief period of NMP after static cold storage in terms of renal injury and function. A recently developed clinical scoring system appears to correlate with renal and tubular function. A prospective clinical phase II trial to investigate the initial graft function after 1 h of NMP or static cold storage in kidneys from donors after circulatory death has been initiated in the United Kingdom. Summary Progress has been made in normothermic kidney perfusion, mainly in experimental settings. These results need to be translated into clinical trials to evaluate long-term NMP and its impact in human organs. Future investigations of optimal perfusion parameters are needed. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.