PANCREAS TRANSPLANTATION: Edited by Andrew L. SingerLive donor kidney – PAK versus SPK how to decide?Stites, Erik; Wiseman, Alexander C. Author Information Division of Renal Diseases and Hypertension, Transplant Center, University of Colorado Denver, Aurora, Colorado, USA Correspondence to Erik Stites, Transplant Center, University of Colorado Denver, Mail Stop F749, AOP 7131, 1635 Aurora Court, Aurora, CO 80045, USA. E-mail: [email protected] Current Opinion in Organ Transplantation 22(4):p 377-381, August 2017. | DOI: 10.1097/MOT.0000000000000435 Buy Metrics Abstract Purpose of review Patients with type 1 diabetes and end stage renal disease face a complex choice when considering the relative risks and benefits of kidney transplant alone with or without subsequent pancreas after kidney transplant (PAK) or simultaneous kidney pancreas transplant (SPK). Recent findings SPK is considered the optimal treatment regarding long-term patient survival, but when also faced with the option of living donor kidney transplant with the potential for PAK later, the ideal option is less clear. Summary This review summarizes the current literature regarding SPK, living donor kidney transplant alone, and PAK transplant outcomes and examines the relative risks of pre- and posttransplant variables that impact patient and graft survival to help inform this complex treatment decision. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.