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Clinical and ethical challenges in heart transplantation from donation after circulatory determined death donors

Large, Stephen; Tsui, Steven; Messer, Simon

Current Opinion in Organ Transplantation: June 2017 - Volume 22 - Issue 3 - p 251–259
doi: 10.1097/MOT.0000000000000417
ORGAN PRESERVATION AND PROCUREMENT: Edited by Gabriel C. Oniscu
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Purpose of review The aim of this study was to describe the development of a clinical programme of heart transplantation from nonheart beating (or donation after circulatory determined death, DCD) donors. DCD is an established practice in abdominal and lung transplantation. The opportunity for sufferers of advanced heart failure provided by DCD heart transplantation is described.

Recent findings Work shows that the arrested DCD heart is viable and has a 30-min tolerance to anoxia at normal body temperature making transplantation possible.

Summary The demonstration of the possibility of DCD heart transplantation and its early clinical success is described.

Surgical Department, Papworth Hospital, Cambridge, UK

Correspondence to Stephen Large, MS, MA, MBA, FRCS, MRCP, Papworth Hospital NHS Foundation Trust, Cambridge CB23 3RE, Cambridgeshire, UK. E-mail: S.large@nhs.net

Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.