Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Organ preservation review

history of organ preservation

Cameron, Andrew M.a; Cornejo, Jose F. Barandiaranb

Current Opinion in Organ Transplantation: April 2015 - Volume 20 - Issue 2 - p 146–151
doi: 10.1097/MOT.0000000000000175
ORGAN PRESERVATION AND PROCUREMENT: Edited by Johnny C. Hong
Buy

Purpose of review To summarize the history of organ preservation and place into this context the current trends in preservation.

Recent findings Multiple large retrospective studies have analyzed cold preservation solutions in an attempt to determine superiority with largely negative results. Experimental and some clinical studies have examined machine perfusion of procured grafts, in both hypothermic and normothermic contexts with variable, but promising, results. Lastly, there are experimental efforts to evaluate mesenchymal stem cell therapy on rehabilitation of marginal donor organs.

Summary New trends in organ preservation may soon translate into more efficient use of the limited donor pool.

aTransplant Surgery Department

bGeneral Surgery Department, The Johns Hopkins Hospital, Baltimore, Maryland, USA

Correspondence to Andrew M. Cameron, MD, PhD, The Johns Hopkins Hospital, Baltimore, MD 21287, USA. Tel: +1 410 349 7240; e-mail: acamero5@jhmi.edu

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.