ORGAN PRESERVATION AND PROCUREMENT: Edited by Johnny C. HongOrgan preservation review history of organ preservationCameron, Andrew M.a; Cornejo, Jose F. BarandiaranbAuthor Information aTransplant Surgery Department bGeneral Surgery Department, The Johns Hopkins Hospital, Baltimore, Maryland, USA Correspondence to Andrew M. Cameron, MD, PhD, The Johns Hopkins Hospital, Baltimore, MD 21287, USA. Tel: +1 410 349 7240; e-mail: [email protected] Current Opinion in Organ Transplantation: April 2015 - Volume 20 - Issue 2 - p 146-151 doi: 10.1097/MOT.0000000000000175 Buy Metrics Abstract Purpose of review To summarize the history of organ preservation and place into this context the current trends in preservation. Recent findings Multiple large retrospective studies have analyzed cold preservation solutions in an attempt to determine superiority with largely negative results. Experimental and some clinical studies have examined machine perfusion of procured grafts, in both hypothermic and normothermic contexts with variable, but promising, results. Lastly, there are experimental efforts to evaluate mesenchymal stem cell therapy on rehabilitation of marginal donor organs. Summary New trends in organ preservation may soon translate into more efficient use of the limited donor pool. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.