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Treating the donor

McKeown, Dermot W.a; Ball, Jonathanb

Current Opinion in Organ Transplantation: April 2014 - Volume 19 - Issue 2 - p 85–91
doi: 10.1097/MOT.0000000000000059

Purpose of review Current pressures of organ supply and demand require maximization of potential for organ donation. The donor population is older and has more significant comorbidity than in the past.

Optimal management of the donor after brain death (DBD) is essential to ensure that the greatest number of organs can be transplanted per donor. Defining evidence-based drugs and techniques to assist this has never been more important.

Recent findings Care of patients with catastrophic brain injury incorporating supportive therapy targeted at specific goals and delivered by experienced specialists provides the best donation outcomes. Such pathways represent best practice critical care applied to this population. In this context, the value of some previously recommended therapies appears questionable and warrants reassessment. Prolonged (>24 h) incorporeal organ conditioning may have significant benefits.

Extracorporeal support in the resuscitation arena is emerging and, in patients who fail to respond, may yield a new source of donors.

Summary Early identification of potential DBD, best practice critical care, and achieving defined treatment goals are associated with more transplantable organs.

Study of a complex intervention like donor management presents significant problems of organization, ethics and consent. This situation is recognized internationally and progress is being made.

aScottish Liver Transplant Unit, Edinburgh Royal Infirmary, Edinburgh

bGeneral and Neurointensive Care, St George's Hospital and Medical School, London, UK

Correspondence to Dr Dermot W. McKeown, Consultant Anaesthetist and Honorary Clinical Senior Lecturer, Scottish Liver Transplant Unit, Edinburgh Royal Infirmary, Edinburgh, UK. E-mail:

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins