Histocompatibility: Edited By Frans ClaasHLAMatchmaker-based definition of structural human leukocyte antigen epitopes detected by alloantibodiesDuquesnoy, René J; Marrari, MarilynAuthor Information Division of Transplantation Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA Correspondence to René J. Duquesnoy, PhD, Professor of Pathology, Immunology and Surgery, Thomas E. Starzl Biomedical Science Tower, Room #W1552, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA Tel: +1 412 647 6148; fax: +1 412 647 1755; e-mail: [email protected] Current Opinion in Organ Transplantation: August 2009 - Volume 14 - Issue 4 - p 403-409 doi: 10.1097/MOT.0b013e32832ca2b8 Buy Metrics Abstract Purpose of review This review addresses the concept that human leukocyte antigen (HLA) antibody specificity should be determined to HLA epitopes rather than HLA antigens. Recent findings HLAMatchmaker is a computer algorithm that considers small configurations of polymorphic residues referred to as eplets as essential components of HLA epitopes. This overview describes recent developments that have increased our understanding of structural epitope antigenicity, that is, reactivity with specific antibody and immunogenicity, that is, its ability to induce an antibody response. Summary A determination of the repertoire of immunogenic epitopes is important for HLA compatibility testing and the identification of acceptable mismatches for sensitized patients. © 2009 Lippincott Williams & Wilkins, Inc.