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Scientific basis of organ preservation

Anaya-Prado, Robertoa; Delgado-Vázquez, Juan Ab

Current Opinion in Organ Transplantation: April 2008 - Volume 13 - Issue 2 - p 129–134
doi: 10.1097/MOT.0b013e3282f6390a
Organ preservation and procurement: Edited by Luis H. Toledo-Pereyra

Purpose of review To review the basic mechanisms involved during hypothermia and reperfusion, with special attention paid to efforts being made in refining solutions and the molecular characterization of cells during preservation.

Recent findings Several graft-related molecules have been identified as correlating with early graft dysfunction and/or poor outcome in the immediate posttransplant period. Also, different inhibitors have been utilized to ameliorate the preservation-induced injury, alone or in combination with different preservation solutions.

Summary Preservation-induced injury is a major contributing factor to early graft dysfunction in organ recipients. The success of organ transplantation is critically dependent on the quality of the donor organ. Donor-organ quality, in turn, is determined by a variety of factors, including donor age, donor management prior to organ procurement, the duration of hypothermic storage, and perfusion techniques utilized to protect organs from ischemia/reperfusion injury, which in turn cause a dramatic reprogramming of cell metabolism during organ transplantation. The expression of a number of inflammatory genes has been associated with early graft dysfunction and/or poor outcome in the immediate postoperative period. Some therapeutic manipulations have been demonstrated to be of significance in attaining near-normal organ function after transplantation.

aDepartment of Research and Education, Western Medical Center at Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico

bDepartment of Surgical Oncology, Instituto Nacional de Cancerología, Mexico

Correspondence to Roberto Anaya-Prado MD, PhD, FACS, Blvd Puerta de Hierro # 5150, Int 201-B, Fracc, Corporativo Zapopan, Zapopan, Jalisco, Mexico, 45110 Tel/fax: +52 33 3848 5410; e-mail:

© 2008 Lippincott Williams & Wilkins, Inc.