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Accommodation in organ transplantation

Lynch, Raymond Ja; Platt, Jeffrey Lb

Current Opinion in Organ Transplantation: April 2008 - Volume 13 - Issue 2 - p 165–170
doi: 10.1097/MOT.0b013e3282f6391e
Xenotransplantation: Edited by Emanuele Cozzi
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Purpose of review We review recent insights into the mechanisms and prevalence of accommodation. Accommodation refers to an acquired resistance of an organ graft to humoral injury and rejection.

Recent findings Accommodation has been postulated to reflect changes in antibodies, control of complement and/or acquired resistance to injury by antibodies, complement or other factors. We discuss the importance of these mechanisms, highlighting new conclusions.

Summary Accommodation may be a common, perhaps the most common, outcome of organ transplantation and, in some systems, a predictable outcome of organ xenotransplantation. Further understanding of how accommodation is induced and by what mechanisms it is manifest and maintained could have a profound impact on transplantation in general and perhaps on other fields.

aDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA

bTransplantation Biology Program and Departments of Surgery, Immunology and Pediatrics, Mayo Clinic, Rochester, Minnesota, USA

Correspondence to Jeffrey L. Platt, MD, Biomedical Sciences Research Bldg., 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA Tel: +1 734 615 6819; fax: +1 734 615 7141; e-mail: Platt.jeffrey@mayo.edu

© 2008 Lippincott Williams & Wilkins, Inc.