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Living-donor lobar lung transplantation

Date, Hiroshi; Yamane, Masaomi; Toyooka, Shinichi; Oto, Takahiro; Sano, Yoshifumi

Current Opinion in Organ Transplantation: October 2007 - Volume 12 - Issue 5 - p 469–472
doi: 10.1097/MOT.0b013e3282ef7bc5
Lung transplantation: Edited by David P. Mason
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Purpose of review To address the donor shortage issue, living-donor lobar lung transplantations have been performed in some institutions. This paper will review the current status of living-donor lobar lung transplantation.

Recent findings Up to 2006, living-donor lobar lung transplantation has been performed in approximately 300 patients worldwide. As only two lobes are transplanted, cystic fibrosis represents the most common indication for living-donor lobar lung transplantation, because patients are usually small in body size. Indications for living-donor lobar lung transplantation have recently been expanded to include paediatric and adult patients with various lung diseases such as idiopathic pulmonary fibrosis and pulmonary arterial hypertension. Survival appears to be similar to or better than International Society for Heart and Lung Transplantation registry data on cadaveric lung transplantation. Living-donor lobar lung transplantation may improve survival after paediatric lung retransplantation. The Vancouver Forum Lung Group proposed the eligibility criteria for living lobar donation.

Summary This procedure can be applied to restrictive, obstructive, infectious, and hypertensive lung diseases for both paediatric and adult patients. As a result of the possible serious complications after donor lobectomy, living-donor lobar lung transplantation should be performed only for very sick patients by a well-prepared programme.

Departments of Cancer and Thoracic Surgery, Okayama University Graduate School, Okayama, Japan

Correspondence to Hiroshi Date, MD, Department of Cancer and Thoracic Surgery (Surgery II), Okayama University Graduate School, 2-5-1 Shikata-Cho, Okayama 700-8558, Japan Tel: +81 86 235 7262; fax: +81 86 235 7268; e-mail: hdate@md.okayama-u.ac.jp

© 2007 Lippincott Williams & Wilkins, Inc.