Despite significant progress in the development of novel cancer treatments, chemotherapy is often utilized for most tumors irrespective of its associated toxicities . It is now clear that chemotherapy plays a direct role in the loss of muscle mass and muscle strength in cancer patients (often referred to as ‘cachexia’), a condition that can persist for months to years following remission [2–9]. Notably, patients suffering from cachexia-related symptoms are often unable to complete treatment regimens and may require delays in treatment, dose limitation, or discontinuation of therapy [10,11]. Several studies have been conducted with the goal of identifying strategies to minimize or prevent cancer therapy toxicities . This review will highlight the mechanistic effects of cancer treatments on body composition and provide potential strategies proposed to limit chemotherapy-related toxicities in cancer patients, including ways to preserve lean body mass (LBM).
CHEMOTHERAPY NEGATIVELY IMPACTS PHYSICAL FUNCTION BY CAUSING IMPAIRED MUSCLE FUNCTION
Chemotherapeutic agents act primarily by antagonizing essential mechanisms of cell division. These antiproliferative and cytotoxic drugs have a high biological activity that lead to ablation of cancer cells, but at the same time are responsible for dramatic toxicities in the host body. Among these side effects, nausea, vomiting, diarrhea, anorexia, body weight changes, and anemia are the most relevant . Notably, muscle weakness and fatigue are some of the most common and distressing symptoms associated with cancer and chemotherapy [14,15], and it is estimated that over 70% of patients receiving cancer treatments will present symptoms associated with these conditions [16,17,18▪▪,19,20]. Because of this, chemotherapy-dependent effects on body composition and on musculoskeletal function have recently become subject of interest . Indeed, muscle dysfunction in cancer patients may affect the overall quality of life, including productivity and physical functioning, and this may be further intensified following chemotherapy [21–27]. In this regard, it has been shown that administration of chemotherapy promotes depletion of skeletal muscle mass in patients affected with advanced tumors, including lung, breast, colorectal, prostate, and nonsmall-cell lung (NSCLC) cancers, and this condition negatively impacts physical function by causing impaired muscle strength (such as slower chair-rise time and reduced hand-grip force), as well as joint dysfunction [2–4,18▪▪,28▪,29]. Unfortunately, no treatments are currently available to relieve such conditions.
PROPER ASSESSMENT OF BODY COMPOSITION IS ESSENTIAL TO PREVENT CHEMOTHERAPY TOXICITY
Experimental and clinical findings suggest that body composition and, in particular, skeletal muscle mass play a pivotal role in the response to chemotherapy and in the prevention of its associated toxicities, as well as in ultimately predicting outcomes and survival of cancer patients. For instance, Du Bois and Du Bois  proposed a method to estimate pharmacokinetics and dosage of a drug by determining the body surface area (BSA) as a relation between height and weight, according to the formula BSA (m2) = ([height (cm2) × weight (kg)]/3600)1/2. Although not optimal, this method is still widely used, especially for dosing of drugs characterized by a low therapeutic index, as in the case of chemotherapeutics, and several modifications were suggested to generate a better approximation of the BSA [31,32].
There remains, however, a potential limitation associated with this dosing method in that it does not take into account the considerable variation in BSA because of changes in fat mass. Indeed, it has been previously demonstrated that the assessment of BSA can overestimate or underestimate the correct drug dosing. This is particularly true for antineoplastic agents, most of which have a narrow therapeutic window, thus leading to low efficacy in case of underdosing or severe side effects in case of overdosing . Along the same line, Chatelut et al. provided evidence that the clearance of different chemotherapeutic agents often poorly correlate with the BSA, thus casting doubt on the effectiveness of this parameter for the dosing of chemotherapy. Another study by Prado et al. also showed that cancer patients presenting with identical BSA may regardless show high variability in LBM, primarily because of significant changes in adipose tissue mass. These findings suggest that accurate body composition assessment is linked to chemotherapy toxicity and survival. Therefore, wasting of skeletal muscle mass, by constituting a smaller volume of distribution for anticancer drugs, may also lead to inadvertent overdosing and exacerbated toxicity. This hypothesis was further supported by more recent evidence showing that patients with low amount of lean tissue at time of cancer diagnosis were also more susceptible to develop side effects following chemotherapy administration . Additionally, the prevalence of dose-limiting toxicities was also shown in a cohort of advanced renal cell carcinoma patients presenting muscle depletion and low lean tissue mass with respect to patients not affected by these conditions .
In order to address the concerns related to the use of BSA for chemotherapy dosing, alternative methods have been proposed, including the assessment of the ideal body weight or the BMI (i.e. weight adjusted for stature, kg/m2). However, all these weight-based metrics do not take into account body mass composition and the relative proportions and distributions of lean, fat and bone mass in the human body [38,39]. As body composition in cancer patients may result highly variable in terms of muscle and fat mass, as well as of distribution of adipose tissue between abdominal and subcutaneous compartments, these factors are likely critical to effectively establish chemotherapy dosing [40▪▪,41]. This is of particular importance in patients with ‘sarcopenic obesity,’ a condition describing individuals that simultaneously present with high fat mass and low muscularity resulting in increased risk for adverse outcomes in the occurrence of cancer [42,43].
Enhanced treatment-associated toxicity and increased mortality in patients affected with different types of cancer have been shown to directly correlate with changes in body composition, primarily muscle mass, and there is also evidence that the amount of adipose tissue may represent a useful predictor of outcomes. Indeed, data generated in patients with metastatic colorectal cancer (mCRC) receiving bevacizumab suggested that low visceral adipose tissue correlates with shorter survival and overall negative outcomes . Sarcopenia is also an indicator of poor outcomes and greater toxicity in patients with nonmetastatic  and resectable stage I–III colorectal tumors , or in patients affected with mCRC and receiving palliative chemotherapy [47▪]. Loss of skeletal muscle or changes in skeletal muscle density (SMD) following systemic chemotherapy treatments were associated with poor survival in patients affected with diffuse large B-cell lymphoma , as well as foregut  and ovarian  cancers. Analogously, in a study conducted on lung cancer patients, chemotherapy treatment preceded the detection of decreased muscle mass and increased adipose tissue. In this context, sarcopenia was correlated with reduced tolerance to chemotherapy treatment and thought to predict a worse prognosis .
As expected, a retrospective analysis of advanced nonsquamous NSCLC patients who received platinum-based therapy in combination with bevacizumab demonstrated that weight gain during or after treatment is a reliable indicator of clinical benefit and improved survival . In a retrospective study including 193 patients affected with unresectable pancreatic cancer showing significant loss of adipose tissue following administration of neoadjuvant treatment, gain in muscle mass was associated with increased chance of resectability and better outcomes [53▪]. Together these findings indicate that proper assessment of body composition is an important factor to consider for the prevention of chemotherapy toxicity.
ANTI-CANCER DRUGS ARE ASSOCIATED WITH MUSCULOSKELETAL DYSFUNCTIONS
Preclinical investigations support a relationship between chemotherapy treatment and the loss of body weight, constituting both LBM and adipose tissue (i.e. cachexia) occurring in the majority of cancer patients. Le Bricon and colleagues were among the first to provide evidence of a link between the administration of chemotherapeutics [such as cyclophosphamide, 5-fluorouracil (5-FU), cisplatin, or methotrexate] and abnormal nitrogen balance in the muscle of tumor-bearing rats leading to significant loss of skeletal muscle mass. Notably, these drug-associated toxicities were exacerbated in the cancer hosts, despite the fact that tumor proliferation was effectively counteracted .
Further, several investigators provided the first mechanistic explanation for the loss of muscle mass observed in tumor hosts exposed to chemotherapeutics. On the basis of these findings, anticancer drugs (including cisplatin, irinotecan, Adriamycin, and etoposide) were shown to cause muscle wasting directly via activation of the NF-κB pathway and independently of the commonly implicated ubiquitin-proteasome system, or indirectly via production of pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF, or by inducing oxidative stress and tissue injury [55–57]. Other independent investigations also proposed that the molecular mechanisms accounting for the loss of muscle size and strength in animals bearing cancer and/or exposed to chemotherapy were correlated with activation of pro-inflammatory pathways, down-regulation of anabolism and exacerbation of muscle proteolysis .
In the attempt to identify some of the mechanisms responsible for the development of cachexia following exposure to chemotherapy, we recently investigated the role of some of the anticancer agents utilized for the treatment of colorectal and other solid tumors, namely FOLFIRI (5-FU, leucovorin, irinotecan) and FOLFOX (5-FU, leucovorin, oxaliplatin) . The administration of these widely used chemotherapy regimens to healthy mice was able to reproduce some of the alterations typical of cancer cachexia, including body weight loss, adipose tissue, skeletal muscle wasting, and weakness. Our evidence showed that the chemotherapy treatment was responsible for hyperactivation of the ERK1/2 signaling pathway, previously involved in the pathogenesis of cachexia , as well as for structural changes in the sarcomeres and for dramatic muscle mitochondrial depletion. Chemotherapy also led to abnormal oxidative metabolism and to an oxidative-to-glycolytic shift in fiber type composition .
Interestingly, these findings were in line with previously published data, suggesting that cancer and chemotherapy may promote the appearance of a cachectic phenotype by activating similar mechanisms . Our observations were also subsequently validated by our comprehensive proteomic profiling aimed at comparing cachexia in a setting of cancer or following chemotherapy . Importantly, trabecular bone tissue was also significantly affected by chemotherapy treatments. For instance, doxorubicin and, in particular, FOLFIRI were recently shown to promote dramatic loss of bone [62,63▪], whereas aromatase inhibitors, usually prescribed as the standard of care in the therapy of postmenopausal breast cancer, were shown to promote osteolysis by activating osteoclast-mediated bone resorption and to exacerbate muscle weakness in animals bearing estrogen-receptor negative breast cancers . Altogether, these findings suggest that administration of compounds with cytotoxic and antiproliferative properties promote muscle and bone derangements by activating a wide range of mechanisms.
PRESERVATION OF MUSCLE MASS AS A TOOL TO COUNTERACT CHEMOTHERAPY TOXICITY
Experimental and clinical data support the importance of the relationship between muscle mass and the response to chemotherapy, thus also suggesting that preservation of muscle mass per se represents a novel strategy to ultimately prevent chemotherapy toxicity and improve quality of life with cancer. Agents targeting skeletal muscle anabolism have been tested with the goal of preserving muscle mass in the presence of cancer and following the treatment with chemotherapy drugs (Fig. 1). In 2008, Garcia et al. proposed the treatment with ghrelin, a potent growth hormone secretagogue endowed with orexigenic and neuroprotective properties, as a method to counteract cisplatin-associated loss of body and muscle weight. The molecular mechanisms involved in determining better muscle phenotype and improved survival in tumor hosts exposed to chemotherapy included down-regulation of inflammation and p38/C/EBP-β/myostatin signaling, as well as activation of Akt and myogenic factors, such as myogenin, and myoD . Another group showed that synthetic agonists of the ghrelin receptor counteract chemotherapy-induced toxicity by effectively preventing calcium dysregulation and mitochondrial damage in skeletal muscle [66,67].
With others, we reported that ACVR2B/Fc potently counteracts muscle wasting in combination with FOLFIRI [63▪], doxorubicin , or cisplatin [68▪]. ACVR2B/Fc is a soluble ACVR2B fusion protein and inhibitor of the activin 2B receptor signaling previously shown to preserve muscle mass and prolong better survival in tumor hosts . Interestingly, our recent studies found that ACVR2B/Fc also exerts powerful protective effects related to the preservation of bone mass in animals chronically administered FOLFIRI in combination with ACVR2B/Fc. These findings further demonstrate that the preservation of muscle mass may provide a tool to counteract chemotherapy toxicity by identifying a potential strategy for the detection of early cancer-associated musculoskeletal deficits following cancer treatments [63▪].
Changes in body composition, mainly resulting in depletion of skeletal muscle mass, have been linked to the use of anticancer drugs. On the basis of a growing number of experimental and clinical studies, there is now substantial agreement on the idea that the loss of lean mass represents an accurate prognostic factor for augmented treatment toxicity, worsened outcomes, and overall reduced survival in cancer patients. In an attempt to identify the molecular causes responsible for musculoskeletal disorders upon treatment with chemotherapy, several research groups have focused their attention on the in-vivo effects of commonly used chemotherapy regimens, including cisplatin, doxorubicin, FOLFIRI. These findings support that muscle size and function are primarily affected by activating signaling pathways that have been previously implicated in promoting muscle atrophy and that are driven by processes that impinge on mitochondrial metabolism and muscle protein homeostasis. A series of promising experimental data also suggests the use of muscle pro-anabolic strategies as powerful tools to spare lean tissue in a setting of cancer or chemotherapy (Fig. 1). However, additional studies are necessary to establish novel methods for the accurate assessment of body composition in patients with cancer, with the ultimate goal of monitoring the changes in fat, muscle, and bone tissue that follow the treatment with chemotherapy. Completion of this endeavor will ultimately allow performing simultaneous adjustment of drug dosing, thus also attaining reduction in musculoskeletal side effects in patients with cancer.
The authors would like to thank ‘Servier Medical Art’ (Les Laboratoires Servier, Suresne, France) for providing free access to their medical images, and John P. Spence, PhD for his precious contribution in editing the manuscript.
Financial support and sponsorship
This study was supported by the Department of Surgery and the Department of Otolaryngology – Head & Neck Surgery at Indiana University, and by grants to A.B. from the V Foundation for Cancer Research (V2017-021), the American Cancer Society (Research Scholar Grant 132013-RSG-18-010-01-CCG) and the Indiana University Simon Cancer Center (IUSCC Associate Member Pilot Funding Mechanism).
Conflicts of interest
There are no conflicts of interest.
REFERENCES AND RECOMMENDED READING
Papers of particular interest, published within the annual period of review, have been highlighted as:
- ▪ of special interest
- ▪▪ of outstanding interest
1. Crawford S. Is it time for a new paradigm for systemic cancer treatment? Lessons from a century of cancer chemotherapy
. Front Pharmacol 2013; 4:68.
2. Brown DJ, McMillan DC, Milroy R. The correlation between fatigue, physical function, the systemic inflammatory response, and psychological distress in patients with advanced lung cancer. Cancer 2005; 103:377–382.
3. Galvao DA, Taaffe DR, Spry N, et al. Reduced muscle strength and functional performance in men with prostate cancer undergoing androgen suppression: a comprehensive cross-sectional investigation. Prostate Cancer Prostatic Dis 2009; 12:198–203.
4. Hayes S, Battistutta D, Newman B. Objective and subjective upper body function six months following diagnosis of breast cancer. Breast Cancer Res Treat 2005; 94:1–10.
5. Knobel H, Havard Loge J, Lund MB, et al. Late medical complications and fatigue in Hodgkin's disease survivors. J Clin Oncol 2001; 19:3226–3233.
6. Luctkar-Flude M, Groll D, Woodend K, Tranmer J. Fatigue and physical activity in older patients with cancer: a six-month follow-up study. Oncol Nurs Forum 2009; 36:194–202.
7. Meeske K, Smith AW, Alfano CM, et al. Fatigue in breast cancer survivors two to five years post diagnosis: a HEAL Study report. Qual Life Res 2007; 16:947–960.
8. Goedendorp MM, Andrykowski MA, Donovan KA, et al. Prolonged impact of chemotherapy
on fatigue in breast cancer survivors: a longitudinal comparison with radiotherapy-treated breast cancer survivors and noncancer controls. Cancer 2012; 118:3833–3841.
9. Barreto R, Waning DL, Gao H, et al. Chemotherapy
is associated with mitochondrial depletion and the activation of ERK1/2 and p38 MAPKs. Oncotarget 2016; 7:43442–43460.
10. Rosenthal MA, Oratz R. Phase II clinical trial of recombinant alpha 2b interferon and 13 cis retinoic acid in patients with metastatic melanoma. Am J Clin Oncol 1998; 21:352–354.
11. Visovsky C, Schneider SM. Cancer-related fatigue. Online J Issues Nurs 2003; 8:8.
12. Cleeland CS, Allen JD, Roberts SA, et al. Reducing the toxicity of cancer therapy: recognizing needs, taking action. Nat Rev Clin Oncol 2012; 9:471–478.
13. Dantzer R, Meagher MW, Cleeland CS. Translational approaches to treatment-induced symptoms in cancer patients. Nat Rev Clin Oncol 2012; 9:414–426.
14. Curt GA, Breitbart W, Cella D, et al. Impact of cancer-related fatigue on the lives of patients: new findings from the fatigue coalition. Oncologist 2000; 5:353–360.
15. Glaus A. Assessment of fatigue in cancer and noncancer patients and in healthy individuals. Support Care Cancer 1993; 1:305–315.
16. Ahlberg K, Ekman T, Gaston-Johansson F, Mock V. Assessment and management of cancer-related fatigue in adults. Lancet 2003; 362:640–650.
17. Stasi R, Abriani L, Beccaglia P, et al. Cancer-related fatigue: evolving concepts in evaluation and treatment. Cancer 2003; 98:1786–1801.
18▪▪. Neefjes ECW, van den Hurk RM, Blauwhoff-Buskermolen S, et al. Muscle mass as a target to reduce fatigue in patients with advanced cancer. J Cachexia
Sarcopenia Muscle 2017; 8:623–629.
This article describes the association between changes in skeletal muscle index (SMI) and cancer-related fatigue (CRF) in male cancer patients undergoing palliative chemotherapy, therefore, suggesting that CRF can be reduced by exercise interventions that may concurrently increase muscle mass.
19. Patrick DL, Ferketich SL, Frame PS, et al. National Institutes of Health State-of-the-Science Conference Statement: Symptom management in cancer: pain, depression, and fatigue, July 15–17, 2002. J Natl Cancer Inst Monogr 2004; 9–16.
20. NHLBI Workshop summary. Respiratory muscle fatigue. Report of the Respiratory Muscle Fatigue Workshop Group. Am Rev Respir Dis 1990; 142:474–480.
21. Jacobsen PB, Donovan KA, Small BJ, et al. Fatigue after treatment for early stage breast cancer: a controlled comparison. Cancer 2007; 110:1851–1859.
22. Prue G, Allen J, Gracey J, et al. Fatigue in gynecological cancer patients during and after anticancer treatment. J Pain Symptom Manage 2010; 39:197–210.
23. Cella D, Peterman A, Passik S, et al. Progress toward guidelines for the management of fatigue. Oncology (Williston Park) 1998; 12:369–377.
24. Jacobsen PB, Hann DM, Azzarello LM, et al. Fatigue in women receiving adjuvant chemotherapy
for breast cancer: characteristics, course, and correlates. J Pain Symptom Manage 1999; 18:233–242.
25. Nail LM. Fatigue in patients with cancer. Oncol Nurs Forum 2002; 29:537.
26. Mock V, Pickett M, Ropka ME, et al. Fatigue and quality of life outcomes of exercise during cancer treatment. Cancer Pract 2001; 9:119–127.
27. Montazeri A. Quality of life data as prognostic indicators of survival in cancer patients: an overview of the literature from 1982 to 2008. Health Qual Life Outcomes 2009; 7:102.
28▪. Klassen O, Schmidt ME, Ulrich CM, et al. Muscle strength in breast cancer patients receiving different treatment regimes. J Cachexia
Sarcopenia Muscle 2017; 8:305–316.
This study provides evidence that muscle functional alterations, frequently associated with chemotherapy treatments, can appear before muscle atrophy becomes evident.
29. Naito T, Okayama T, Aoyama T, et al. Skeletal muscle
depletion during chemotherapy
has a large impact on physical function in elderly Japanese patients with advanced nonsmall-cell lung cancer. BMC cancer 2017; 17:571.
30. Du Bois D, Du Bois EF. A formula to estimate the approximate surface area if height and weight be known. 1916. Nutrition 1989; 5:303–311.
31. Felici A, Verweij J, Sparreboom A. Dosing strategies for anticancer drugs: the good, the bad and body-surface area. Eur J Cancer 2002; 38:1677–1684.
32. Ratain MJ. Body-surface area as a basis for dosing of anticancer agents: science, myth, or habit? J Clin Oncol 1998; 16:2297–2298.
33. Thoresen L, Frykholm G, Lydersen S, et al. Nutritional status, cachexia
and survival in patients with advanced colorectal carcinoma. Different assessment criteria for nutritional status provide unequal results. Clin Nutr 2013; 32:65–72.
34. Chatelut E, White-Koning ML, Mathijssen RH, et al. Dose banding as an alternative to body surface area-based dosing of chemotherapeutic agents. Br J Cancer 2012; 107:1100–1106.
35. Prado CM, Lieffers JR, McCargar LJ, et al. Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. Lancet Oncol 2008; 9:629–635.
36. Prado CM, Baracos VE, McCargar LJ, et al. Body composition
as an independent determinant of 5-fluorouracil-based chemotherapy
toxicity. Clin Cancer Res 2007; 13:3264–3268.
37. Antoun S, Baracos VE, Birdsell L, et al. Low body mass index and sarcopenia associated with dose-limiting toxicity of sorafenib in patients with renal cell carcinoma. Ann Oncol 2010; 21:1594–1598.
38. Rier HN, Jager A, Sleijfer S, et al. The prevalence and prognostic value of low muscle mass in cancer patients: a review of the literature. Oncologist 2016; 21:1396–1409.
39. Sandini M, Bernasconi DP, Fior D, et al. A high visceral adipose tissue-to-skeletal muscle
ratio as a determinant of major complications after pancreatoduodenectomy for cancer. Nutrition 2016; 32:1231–1237.
40▪▪. Ali R, Baracos VE, Sawyer MB, et al. Lean body mass as an independent determinant of dose-limiting toxicity and neuropathy in patients with colon cancer treated with FOLFOX regimens. Cancer Med 2016; 5:607–616.
The data reported in this study aim at determining whether changes in lean body mass (LBM) correlate with dose-limiting toxicity in patients with colon cancer treated with FOLFOX. The conclusions show that low LBM is a significant predictor of toxicity and neuropathy in patients administered FOLFOX-based regimens using conventional body surface area dosing.
41. Martin L, Birdsell L, Macdonald N, et al. Cancer cachexia
in the age of obesity: skeletal muscle
depletion is a powerful prognostic factor, independent of body mass index. J Clin Oncology 2013; 31:1539–1547.
42. Baracos VE, Arribas L. Sarcopenic obesity: hidden muscle wasting and its impact for survival and complications of cancer therapy. Ann Oncol 2018; 29 (Suppl 2):ii1–ii9.
43. Anandavadivelan P, Brismar TB, Nilsson M, et al. Sarcopenic obesity: a probable risk factor for dose limiting toxicity during neo-adjuvant chemotherapy
in oesophageal cancer patients. Clin Nutr 2016; 35:724–730.
44. Miyamoto Y, Oki E, Emi Y, et al. Low visceral fat content is a negative predictive marker for bevacizumab in metastatic colorectal cancer. Anticancer Res 2018; 38:491–499.
45. Cespedes Feliciano EM, Lee VS, Prado CM, et al. Muscle mass at the time of diagnosis of nonmetastatic colon cancer and early discontinuation of chemotherapy
, delays, and dose reductions on adjuvant FOLFOX: the C-SCANS study. Cancer 2017; 123:4868–4877.
46. Miyamoto Y, Baba Y, Sakamoto Y, et al. Sarcopenia is a negative prognostic factor after curative resection of colorectal cancer. Ann Surg Oncol 2015; 22:2663–2668.
47▪. Blauwhoff-Buskermolen S, Versteeg KS, de van der Schueren MA, et al. Loss of muscle mass during chemotherapy
is predictive for poor survival of patients with metastatic colorectal cancer. J Clin Oncol 2016; 34:1339–1344.
This is an important study showing that muscle size is significantly affected during chemotherapy and represents an independent predictor of survival in patients with metastatic colorectal cancer (mCRC).
48. Chu MP, Lieffers J, Ghosh S, et al. Skeletal muscle
density is an independent predictor of diffuse large B-cell lymphoma outcomes treated with rituximab-based chemoimmunotherapy. J Cachexia
Sarcopenia Muscle 2017; 8:298–304.
49. Daly LE, Ni Bhuachalla EB, Power DG, et al. Loss of skeletal muscle
during systemic chemotherapy
is prognostic of poor survival in patients with foregut cancer. J Cachexia
Sarcopenia Muscle 2018; 9:315–325.
50. Rutten IJG, van Dijk DPJ, Kruitwagen RFPM, et al. Loss of skeletal muscle
during neoadjuvant chemotherapy
is related to decreased survival in ovarian cancer patients. J Cachexia
Sarcopenia Muscle 2016; 7:458–466.
51. Nattenmuller J, Wochner R, Muley T, et al. Prognostic impact of CT-quantified muscle and fat distribution before and after first-line-chemotherapy
in lung cancer patients. PloS One 2017; 12:e0169136.
52. Patel JD, Pereira JR, Chen J, et al. Relationship between efficacy outcomes and weight gain during treatment of advanced, nonsquamous, nonsmall-cell lung cancer patients. Ann Oncol 2016; 27:1612–1619.
53▪. Sandini M, Patino M, Ferrone CR, et al. Association between changes in body composition
and neoadjuvant treatment for pancreatic cancer. JAMA Surg 2018; [Epub ahead of print].
In this article, the gain in muscle mass following neoadjuvant treatments positively correlates with increased success of tumor resection and overall survival in pancreatic cancer patients.
54. Le Bricon T, Gugins S, Cynober L, Baracos VE. Negative impact of cancer chemotherapy
on protein metabolism in healthy and tumor-bearing rats. Metabolism 1995; 44:1340–1348.
55. Sultani M, Stringer AM, Bowen JM, Gibson RJ. Anti-inflammatory cytokines: important immunoregulatory factors contributing to chemotherapy
-induced gastrointestinal mucositis. Chemother Res Pract 2012; 2012:490804.
56. Damrauer JS, Stadler ME, Acharyya S, et al. Chemotherapy
-induced muscle wasting: association with NF-kB and cancer cachexia
. Basic Appl Myol 2008; 18:139–148.
57. Gilliam LA, St Clair DK. Chemotherapy
-induced weakness and fatigue in skeletal muscle
: the role of oxidative stress. Antioxid Redox Signal 2011; 15:2543–2563.
58. Chen JA, Splenser A, Guillory B, et al. Ghrelin prevents tumour- and cisplatin-induced muscle wasting: characterization of multiple mechanisms involved. J Cachexia
Sarcopenia Muscle 2015; 6:132–143.
59. Penna F, Costamagna D, Fanzani A, et al. Muscle wasting and impaired myogenesis in tumor bearing mice are prevented by ERK inhibition. PloS One 2010; 5:e13604.
60. Pin F, Busquets S, Toledo M, et al. Combination of exercise training and erythropoietin prevents cancer-induced muscle alterations. Oncotarget 2015; 6:43202–43215.
61. Barreto R, Mandili G, Witzmann FA, et al. Cancer and chemotherapy
contribute to muscle loss by activating common signaling pathways. Front Physiol 2016; 7:472.
62. Nissinen TA, Degerman J, Rasanen M, et al. Systemic blockade of ACVR2B ligands prevents chemotherapy
-induced muscle wasting by restoring muscle protein synthesis without affecting oxidative capacity or atrogenes. Sci Rep 2016; 6:32695.
63▪. Barreto R, Kitase Y, Matsumoto T, et al. ACVR2B/Fc counteracts chemotherapy
-induced loss of muscle and bone mass. Sci Rep 2017; 7:14470.
This study reports bone loss as consequence of chronic administration of anticancer drugs and shows that pro-anabolic strategies may reduce the occurrence of musculoskeletal defects following chemotherapy.
64. Wright LE, Harhash AA, Kozlow WM, et al. Aromatase inhibitor-induced bone loss increases the progression of estrogen receptor-negative breast cancer in bone and exacerbates muscle weakness in vivo. Oncotarget 2017; 8:8406–8419.
65. Garcia JM, Cata JP, Dougherty PM, Smith RG. Ghrelin prevents cisplatin-induced mechanical hyperalgesia and cachexia
. Endocrinology 2008; 149:455–460.
66. Sirago G, Conte E, Fracasso F, et al. Growth hormone secretagogues hexarelin and JMV2894 protect skeletal muscle
from mitochondrial damages in a rat model of cisplatin-induced cachexia
. Sci Rep 2017; 7:13017.
67. Conte E, Camerino GM, Mele A, et al. Growth hormone secretagogues prevent dysregulation of skeletal muscle
calcium homeostasis in a rat model of cisplatin-induced cachexia
. J Cachexia
Sarcopenia Muscle 2017; 8:386–404.
68▪. Hatakeyama S, Summermatter S, Jourdain M, et al. ActRII blockade protects mice from cancer cachexia
and prolongs survival in the presence of anticancer treatments. Skelet Muscle 2016; 6:26.
This was the first study to suggest the use of ActRII blockade for the preservation of muscle mass and the reduction of muscle toxicities in the presence of anticancer therapies.
69. Benny Klimek ME, Aydogdu T, Link MJ, et al. Acute inhibition of myostatin-family proteins preserves skeletal muscle
in mouse models of cancer cachexia
. Biochem Biophys Res Commun 2010; 391:1548–1554.