Special commentaryTherapeutic strategies for advanced penile carcinomaDelacroix, Scott E Jr; Pettaway, Curtis AAuthor Information M.D. Anderson Cancer Center, University of Texas, Houston, Texas, USA Correspondence to Curtis A. Pettaway, MD, Professor, Urology, University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1373, Houston, TX 77030, USA E-mail: email@example.com Current Opinion in Supportive and Palliative Care: December 2010 - Volume 4 - Issue 4 - p 285-292 doi: 10.1097/SPC.0b013e32833efcca Buy Metrics Abstract Purpose of review The article will review the treatment of regionally advanced squamous cell carcinoma (SCC) of the penis and will highlight contemporary therapeutic strategies in advanced penile carcinoma. Recent findings Advanced penile cancer as defined by bulky inguinal or pelvic metastasis is treated in a systematic fashion by integrating systemic and local therapies. Contemporary series show the morbidity from consolidative surgery has been reduced, whereas the integration of neoadjuvant and adjuvant therapies may provide improved cancer-specific outcomes over single modality treatment. Multiple clinical and pathologic features guide the treatment of advanced disease and aid in determining the appropriate use of neoadjuvant or adjuvant therapies. Summary The current treatment of advanced SCC of the penis has evolved to include multimodal treatments for patients with advanced locoregional disease. © 2010 Lippincott Williams & Wilkins, Inc.