Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Cognitive adverse effects of chemotherapy in breast cancer patients

Correa, Denise Da; Ahles, Tim Ab

Current Opinion in Supportive and Palliative Care: April 2007 - Volume 1 - Issue 1 - p 57–62
doi: 10.1097/SPC.0b013e32813a328f
Psychological and cognitive problems
Buy

Purpose of review This article reviews the most recent literature on chemotherapy-associated cognitive changes in women with breast cancer.

Recent findings Most cross-sectional studies reported neuropsychological impairment in patients treated with chemotherapy, but the prevalence was variable. Prospective studies documented cognitive dysfunction in subgroups of patients treated with chemotherapy, but other reports found no evidence of impairment. Studies using neuroimaging techniques and animal models have begun to examine structural and functional correlates of cognitive changes associated with chemotherapy.

Summary Significant advances have been made in the study of chemotherapy-related cognitive dysfunction over the past 10 years. The investigation of additional factors that may contribute to cognitive outcome, such as the effects of treatments other than chemotherapy and genetic susceptibility, is likely to further advance the field.

aDepartment of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA

bDepartment of Psychiatry and Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, New York, USA

Correspondence to Tim A. Ahles PhD, Department of Psychiatry and Behavioral Sciences, Neurocognitive Research Laboratory, Memorial Sloan-Kettering Cancer Center, 641 Lexington Avenue, 7th Floor, New York, NY 10022, USA E-mail: ahlest@mskcc.org

© 2007 Lippincott Williams & Wilkins, Inc.