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Major vessel involvement in Behçet's disease: an update

Calamia, Kenneth Ta; Schirmer, Michaelb; Melikoglu, Melikec

Current Opinion in Rheumatology: January 2011 - Volume 23 - Issue 1 - p 24–31
doi: 10.1097/BOR.0b013e3283410088
Vasculitis syndromes: Edited by Carlo Salvarani

Purpose of review Large vessel vasculitis occurs in a subgroup of patients with Behçet's disease who are at high risk for disease-related morbidity and mortality. Recognition of patients at risk, early detection of vasculitis, and aggressive treatment are essential for optimal care of these patients. We review the expanding knowledge on large vessel problems in Behçet's disease, highlighting recent contributions.

Recent findings Vasculo-Behçet patients are at risk for multiple vessel-related complications including thromboses, stenoses, occlusions, and aneurysms. The primary reason for clot seems to be an inflammatory process in the vessel wall. Less invasive endovascular procedures are increasingly used to treat aneurysms in Behçet patients.

Summary Because of earlier recognition, aggressive medical treatment, and novel surgical procedures, the morbidity and mortality of large vessel vasculitis in Behçet's disease are improving.

aMayo Clinic College of Medicine, Jacksonville, Florida, USA

bInnsbruck Medical University, Innsbruck, Austria

cCerrahpaşa Faculty of Medicine, University of Istanbul, Istanbul, Turkey

Correspondence to Kenneth T. Calamia, MD, Associate Professor of Medicine, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32225, USA Tel: +1 904 953 2062; fax: +1 904 953 0665; e-mail: calamia@mayo.edu

© 2011 Lippincott Williams & Wilkins, Inc.