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Relapsing polychondritis

Kent, Peter D.; Michet, , Clement J. Jr; Luthra, Harvinder S.

Current Opinion in Rheumatology: January 2004 - Volume 16 - Issue 1 - p 56-61
Systemic disorders with rheumatic manifestations
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Relapsing polychondritis is a unique, rare autoimmune disorder in which the cartilaginous tissues are the primary targets of destruction but the immune damage can spread to involve noncartilaginous tissues like the kidney, blood vessels, and so forth. The manifestations of the disease can take many different forms and the pathogenesis is still unclear. It may occur in a primary form or it may be associated with other disease states. This article summarizes important aspects of the disease with a focus on recent information regarding clinical manifestations, disease associations, pathogenesis, and advances in therapeutics.

Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA

Correspondence to Harvinder S. Luthra, MD, Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, 200 1st Street SW, Rochester, MN 59905, USA

Tel: 507 284 3389; fax: 507 284 0564; e-mail: luthra@mayo.edu

© 2004 Lippincott Williams & Wilkins, Inc.