RAYNAUD PHENOMENON, SCLERODERMA, OVERLAP SYNDROMES AND OTHER FIBROSING SYNDROMES: Edited by Shervin AssassiGastrointestinal involvement in systemic sclerosis: pathogenesis, assessment and treatmentVolkmann, Elizabeth R.a; McMahan, Zsuzsannab Author Information aDivision of Rheumatology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California bDivision of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Correspondence to Elizabeth R. Volkmann, MD, MS, 1000 Veteran Ave., Ste 32-59, Los Angeles, CA 90024, USA. Tel: +1 310 825 2448; e-mail: [email protected] Current Opinion in Rheumatology 34(6):p 328-336, November 2022. | DOI: 10.1097/BOR.0000000000000899 Buy Metrics Abstract Purpose of review The majority of patients with systemic sclerosis (SSc) will experience involvement of their gastrointestinal over the course of their disease. Despite the high prevalence of gastrointestinal involvement in SSc, the strategies pertaining to the assessment and treatment for this clinical dimension of SSc have historically been limited. However, the present review highlights recent research contributions that enhance our understanding of SSc-GI patient subsets and provides updates on pathogenic mechanisms of disease, assessment and symptom-directed management. Recent findings In the past few years, several studies have identified risk factors for more severe gastrointestinal disease in SSc and have provided insight to optimize diagnosis and management of SSc-GI symptoms. This article also provides a review of currently available investigations and therapies for individual SSc-GI disease manifestations and reflects on actively evolving areas of research, including our understanding the role of the gut microbiome in SSc. Summary Here, we provide important updates pertaining to the risk stratification, assessment, diagnosis and management of SSc patients with gastrointestinal symptoms. These findings provide opportunities to enhance patient care and highlight exciting opportunities for future research. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.