VASCULITIS SYNDROMES: Edited by Hasan Yazici and Yusuf Yazici2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria sets for three types of antineutrophilic cytoplasmic antibody-associated vasculitisYazici, Hasana; Tascilar, Korayb; Yazici, Yusufc Author Information aAcademic Hospital, Internal Medicine (Rheumatology), Istanbul, Turkey bDepartment of Internal Medicine 3, Friedrich– Alexander University Erlangen– Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany cDivision of Rheumatology, NYU Grossman School of Medicine, New York, USA Correspondence to Hasan Yazici, MD, Academic Hospital, Internal Medicine (Rheumatology), Nuhkuyusu cad. No: 94 Uskudar, Istanbul 34 464, Turkey. Tel/. fax: +90 216 6510000; e-mail: [email protected] Current Opinion in Rheumatology 35(1):p 1-5, January 2023. | DOI: 10.1097/BOR.0000000000000916 Buy Metrics Abstract Purpose of review A critique of the recently published classification criteria for three main types of antineutrophilic cytoplasmic antibody (ANCA)-associated vasculitis. Recent findings An ACR and EULAR joint task force recently published classification criteria for three main types of ANCA-associated vasculitis. The criteria were based on patient histories and findings in nearly 7000 patients from 136 sites in 32 countries. As such the study represented hitherto the most intensive attempt to prepare classification criteria vasculitis. We propose, this truly intensive effort was, unfortunately, unsuccessful. There were two main mishaps. The first one was that the proposed criteria were not validated in an independent cohort. This is curious in that the sponsors, ACR and EULAR, require such independent cohorts for validation. The second mishap is that the concept that disease classification criteria need to be 100% sensitive and specific for a diagnosis is unrealistic. Moreover, all-purpose disease classification criteria are not respectful to scientific research and to the probabilistic nature of the art and the science of medicine. Summary The new ACR/EULAR ANCA-associated vasculitis guidelines have not been validated in independent cohorts. We propose replacing the term disease criteria with disease guidelines. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.