RAYNAUD PHENOMENON, SCLERODERMA, OVERLAP SYNDROMES AND OTHER FIBROSING SYNDROMES: Edited by Shervin AssassiScleroderma autoantibodies in guiding monitoring and treatment decisionsShah, Shivania; Denton, Christopher P.b Author Information aRoyal Free Hospital bRoyal Free Hospital and University College London, London, UK Correspondence to Prof. Christopher P. Denton, Centre for Rheumatology, Division of Medicine, University College London, Royal Free Campus, Hampstead, London NW3 2PF, UK. Tel: +44 20 7794 0432; e-mail: [email protected] Current Opinion in Rheumatology 34(6):p 302-310, November 2022. | DOI: 10.1097/BOR.0000000000000904 Buy Metrics Abstract Purpose of review One of the key clinical challenges of systemic sclerosis (SSc) is diversity in clinical presentation, organ involvement and disease progression. Antinuclear autoantibodies (ANA) are central to the diagnosis of SSc. ANA specificities associated with distinct clinical patterns of organ and skin involvement. Understanding of the molecular differences and pathogenesis of scleroderma has helped further inform clinical acumen. Here, we provide an update on ANA on clinical profiling, management and future direction of SSc. Recent findings There has been further development in delineating clinical patterns in ANA, genetic susceptibility and antigen triggers predisposing to ANA subtypes. Sub-group analysis of recent clinical trials shows differing treatment responses to novel therapeutics. Summary ANA subtyping is likely to be firmly embedded into future classification systems. Beyond informing current management and monitoring of scleroderma patients, ANA subsets have implication on future research and clinical trial design. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.