VASCULITIS SYNDROMES: Edited by Hasan Yazici and Yusuf YaziciAortitis: an updateErdogan, Mustafa Author Information Department of Rheumatology, Basaksehir Cam ve Sakura City Hospital, Istanbul, Turkey Correspondence to Mustafa Erdogan, Department of Rheumatology, Basaksehir Cam ve Sakura City Hospital, 34480 Istanbul, Turkey. E-mail: [email protected] Current Opinion in Rheumatology 33(1):p 34-40, January 2021. | DOI: 10.1097/BOR.0000000000000762 Buy Metrics Abstract Purpose of review Aortitis is the inflammation of the aorta due to various causes. Clinical presentations vary as well as the imaging findings. Exact pathogenetic mechanisms or triggering factors, as well as the best diagnostic and monitoring modalities and treatment strategies, are yet to be elucidated. We reviewed recent studies in aortitis and associated diseases. Recent findings Multiple cohort studies reporting long-term outcomes in patients with noninfectious aortitis were recently published. Comparative features of isolated aortitis were described. Six angiographic clusters for giant cell arteritis and Takayasu have been identified. New classification criteria have been proposed for IgG4-related disease by a data-driven method. The ultrasonographic slope sign and a halo score were described as specific imaging parameters in giant cell arteritis. The promising role of PET-computed tomography, not only in the diagnosis of aortitis but also in monitoring disease activity, has been noted. Results of in-vitro studies on Janus kinase (JAK)/signal transducers and activators of transcription and mammalian target of rapamycin (mTOR) pathways, comparative studies with leflunomide as an induction therapy, and a long-term follow-up study with tocilizumab may contribute to the management of Takayasu arteritis. Summary An impressive number of studies have addressed aortitis in recent years. However, there still is a lack of robust data on causes, monitoring disease activity by imaging and biomarkers, and drugs providing steroid-free remission in noninfectious aortitis. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
