VASCULITIS SYNDROMES: Edited by Hasan Yazici and Yusuf YaziciCentral nervous system vasculitis advances in diagnosisHajj-Ali, Rula A.; Calabrese, Leonard H.Author Information Department of Rheumatic and Immunologic Diseases, Orthopedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, Ohio, USA Correspondence to Leonard H. Calabrese, DO, Department of Rheumatic and Immunologic Diseases, Orthopedic and Rheumatologic Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Tel: +1 216 4445258; e-mail: firstname.lastname@example.org Current Opinion in Rheumatology: January 2020 - Volume 32 - Issue 1 - p 41–46 doi: 10.1097/BOR.0000000000000676 Buy Metrics Abstract Purpose of review The main purpose of this review is to present advances in diagnostics of central nervous system vasculitis (CNS-V). Recent findings Progress in molecular technologies and neuroimaging have added formidably to our knowledge of CNS-V. Next-generation sequencing has the promise to enhance our ability to diagnose, interrogate, and track infectious diseases, making this test attractive and capable of avoiding brain biopsy in cases where CNS infections are suspected. Further the continuum of neuroimaging progress has advanced our ability to diagnose CNS-V. Our capability to visualize the vessel wall have added a great value in differentiating inflammatory from noninflammatory vasculopathies. New genetic variations are being exposed with exome and genome sequences which will aid future diagnosis. Summary We have witnessed tremendous advances in CNS-V mainly by our ability to rule out mimics. Progress in molecular technologies, neuroimaging and genetic studies will continue to enhance the field further. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.