RAYNAUD PHENOMENON, SCLERODERMA, OVERLAP SYNDROMES AND OTHER FIBROSING SYNDROMES: Edited by John VargaCalcinosis in scleroderma made crystal clearHsu, Viviena; Varga, Johnb; Schlesinger, NaomiaAuthor Information aDepartment of Medicine, Rheumatology Division, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey bDepartment of Medicine, Rheumatology Division, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA Correspondence to Vivien Hsu, Department of Medicine, Rheumatology Division, Rutgers Robert Wood Johnson Medical School, 125 Paterson Street, MEB 458, New Brunswick, NJ 08903, USA. E-mail: firstname.lastname@example.org Current Opinion in Rheumatology: November 2019 - Volume 31 - Issue 6 - p 589–594 doi: 10.1097/BOR.0000000000000658 Buy Metrics Abstract Purpose of review Review the current state of knowledge and recent developments in the field of scleroderma-related calcinosis [systemic sclerosis (SSc)-calcinosis], focusing on emerging information related to pathophysiology. Recent findings Recent studies have begun to characterize that factors that regulate ectopic mineralization, and those that underlie the imbalance of promoters and inhibitors of this process in SSc. Summary Calcinosis cutis due to ectopic mineralization is a common and highly troublesome complication of SSc. Despite its significant prevalence and clinical impact, the pathogenesis is poorly understood and effective treatment is lacking. More research to better understand the pathophysiology is needed for the identification of novel management strategies for this severe complication of SSc. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.