IMMUNOPATHOGENESIS AND TREATMENT OF AUTOIMMUNE DISEASES: Edited by George C. TsokosGene-function studies in systemic lupus erythematosusRosetti, Florenciaa; de la Cruz, Abigailb; Crispín, José C.aAuthor Information aDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán bPlan de Estudios Combinados en Medicina (PECEM), Facultad de Medicina, UNAM, Mexico City, Mexico Correspondence to Dr José C. Crispín, Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Mexico City 14080, Mexico. Tel: +52 5554870900 x2610; e-mail: [email protected] Current Opinion in Rheumatology: March 2019 - Volume 31 - Issue 2 - p 185-192 doi: 10.1097/BOR.0000000000000572 Buy Metrics Abstract Purpose of review The aim of this review is to discuss recent developments in our understanding of how systemic lupus erythematosus (SLE)-associated genes contribute to autoimmunity. Recent findings Gene-function studies have revealed mechanisms through which SLE-associated alleles of IFIH1, TNFAIP3, IRF5, and PRDM1 likely contribute to the development of autoimmunity. Novel research has identified Mac-1 (encoded by ITGAM), CaMK4, and iRhom2 as plausible therapeutic targets in lupus nephritis. Summary The work discussed in this review has broad implications for our understanding of the pathogenesis of SLE and for the development of novel therapeutic strategies. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.