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Systemic vasculitis and the lung

Talarico, Rosaria; Barsotti, Simone; Elefante, Elena; Baldini, Chiara; Tani, Chiara; Mosca, Marta

Current Opinion in Rheumatology: January 2017 - Volume 29 - Issue 1 - p 45–50
doi: 10.1097/BOR.0000000000000342
VASCULITIS SYNDROMES: Edited by Hasan Yazici and Yusuf Yazici
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Purpose of review The purpose of this review is to provide a critical analysis of the recent literature on this topic, with particular focus on the most relevant studies published over the last year.

Recent findings Many studies are published every year on the diagnosis, pathogenesis and treatment of pulmonary involvement in antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV). The main subjects covered by this article are the pathogenesis, diagnosis and clinical aspects of lung involvement in ANCA-associated vasculitis and non-ANCA-associated vasculitis.

Summary Lung involvement is a common feature in systemic vasculitis. The lungs are one of the most frequently involved organs in systemic vasculitis. In order to provide an update on the recent advances in the pathogenesis, clinical features and novel treatments of lung involvement in systemic vasculitis, a systematic MedLine search has been performed.

Most of the data analyzed have confirmed that lung involvement seems to develop more frequently in patients with myeloperoxidase-ANCA-positive AAV, mainly in those with a diagnosis of microscopic polyangiitis (MPA), compared with patients with proteinase 3 ANCA-positive AAV. Moreover, among non-ANCA-associated vasculitis lung involvement may represent a worrying complication of the disease, mainly when associated with vascular involvement.

aRheumatology Unit, University of Pisa, Pisa

bDepartment of Medical Biotechnologies, University of Siena, Siena, Italy

Correspondence to Rosaria Talarico, Rheumatology Unit, University of Pisa, Via Roma 67, 56126, Pisa, Italy. Tel: +39 3383062729; e-mail: sara.talarico76@gmail.com

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