IMMUNOPATHOGENESIS AND TREATMENT OF AUTOIMMUNE DISEASES: Edited by Iain McInnesThe role of the synovial fibroblast in rheumatoid arthritis pathogenesisTurner, Jason D.a; Filer, Andrewa,bAuthor Information aCentre for Translational Inflammation Research, The University of Birmingham bUniversity Hospitals Birmingham NHS Foundation Trust, New Queen Elizabeth Hospital, Edgbaston, Birmingham, UK Correspondence to Andrew Filer, Senior Lecturer, Centre for Translational Inflammation Research, The University of Birmingham, New Queen Elizabeth Hospital, Mindelsohn Way, Birmingham B15 2WB, UK. Tel: +44 1213713221; fax: +44 1213713203; e-mail: [email protected] Current Opinion in Rheumatology: March 2015 - Volume 27 - Issue 2 - p 175-182 doi: 10.1097/BOR.0000000000000148 Buy Metrics Abstract Purpose of review Synovial fibroblasts continue to grow in prominence both as the subjects of research into the pathogenesis of rheumatoid arthritis and as novel therapeutic targets. This timely review aims to integrate the most recent findings with existing paradigms of fibroblast-related mechanisms of disease. Recent findings Linking the role of synovial fibroblasts as innate sentinels expressing pattern recognition receptors such as toll-like receptors to their effector roles in joint damage and interactions with leukocyte subpopulations has continued to advance. Understanding of the mechanisms underlying increased fibroblast survival in the inflamed synovium has led to therapeutic strategies such as cyclin-dependent kinase inhibition. Major advances have taken place in understanding of the interactions between epigenetic and micro-RNA regulation of transcription in synovial fibroblasts, improving our understanding of the unique pathological phenotype of these cells. Finally, the impact of new markers for fibroblast subpopulations is beginning to become apparent, offering the potential for targeting of pathological cells as the roles of different populations become clearer. Summary Over the past 2 years, major advances have continued to emerge in understanding of the relationship between synovial fibroblasts and the regulation of inflammatory pathways in the rheumatoid arthritis synovium. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.