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New treatment paradigms in psoriatic arthritis

an update on new therapeutics approved by the U.S. Food and Drug Administration

Felquer, Maria L. Acostaa,b; Soriano, Enrique R.a,b

Current Opinion in Rheumatology: March 2015 - Volume 27 - Issue 2 - p 99–106
doi: 10.1097/BOR.0000000000000151
EPIDEMIOLOGY AND HEALTH-RELATED SERVICES: Edited by M. Elaine Husni
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Purpose of review The purpose of this study is to give an overview of the new treatments approved by the U.S. Food and Drug Administration (FDA) for use in psoriatic arthritis (PsA).

Recent findings FDA has approved three new drugs for PsA: Certolizumab-pegol: a PEGylated Fc-free tumour necrosis factor inhibitor (TNFi); ustekinumab: an anti interleukin (IL)-12 and IL-23 mAb; and apremilast and oral phosphodiesterase 4 inhibitor. On well designed and extensive developing programmes, all three drugs proved to be effective for the treatment of most PsA manifestations, including peripheral arthritis, skin involvement, enthesitis, dactylitis, quality of life and radiographic progression in patients failing traditional disease modifying drugs (DMARDs) and TNFi. Safety profile of all three drugs seems to be reassuring until now, although long-term data are still not available. Although Certolizumab-pegol is likely to be placed among the other TNFi, ustekinumab and apremilast, due to lower efficacy on arthritis, are being more frequently used as second-line therapy after TNFi failure, especially among rheumatologists.

Summary There are new therapeutic options approved for the treatment of PsA. For the first time, well proved effective therapies with a different mechanism of action than the inhibition of TNF alpha are available for the treatment of this progressive disease.

aRheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Insituto Universitario Hospital Italiano de Buenos Aires

bFundacion P.M. Catoggio, para el progreso de la Reumatologia, Buenos Aires, Argentina

Correspondence to Enrique R. Soriano, Peron 4190, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina 1181. Tel: +541149590378; e-mail: enrique.soriano@hospitalitaliano.org.ar

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