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An update on inflammatory myositis in children

Huber, Adama; Feldman, Brian M.b , c

doi: 10.1097/BOR.0b013e3283635634

Purpose of review Childhood myositis (juvenile idiopathic inflammatory myopathies – JIIMs) is a rare, but important, group of rheumatic diseases. There has been continuing worldwide progress in the understanding of these diseases, and continuing pursuit of better therapies. We review some important contributions from the recent published literature.

Recent findings Environmental triggers are present in the majority of children with myositis. Cancer is almost never a cause. Newer findings implicate a host of immunologic aberrations, perhaps driven by type I interferons, in addition to the humoral immunity long associated with juvenile dermatomyositis (JDM). Myositis-specific antibodies, once thought to be rare in JIIM, are now found in a significant minority because of the characterization of new antibodies. Although mortality is low, recent studies highlight the accumulation of tissue damage that occurs in JDM. Biologic therapies have an unclear place in the treatment of JIIM, but new protocols are being studied and may lead to better outcomes. Physical exercise, once controversial, likely has a role to play in treatment.

Summary International work is continuing to expand our knowledge of the JIIM.

aDivision of Rheumatology, IWK Health Centre and Dalhousie University, Halifax, Nova Scotia, Canada

bInstitute of Health Policy, Management and Evaluation, and the Dalla Lana School of Public Health, Department of Pediatrics University of Toronto

cDivision of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada

Correspondence to Dr Brian Feldman, MD, MSc, FRCPC, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada. Tel: +1 416 813 6117; fax: +1 416 813 4989; e-mail:

© 2013 Lippincott Williams & Wilkins, Inc.