Systemic lupus erythematosus and Sjögren's syndromeEstrogen and CD4+ T cellsPernis, Alessandra BAuthor Information Department of Medicine, Columbia University, New York, New York, USA Correspondence to Dr Alessandra Pernis, Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA Tel: +1 212 305 3763; fax: +1 212 305 4478; e-mail: [email protected] Current Opinion in Rheumatology: September 2007 - Volume 19 - Issue 5 - p 414-420 doi: 10.1097/BOR.0b013e328277ef2a Buy Metrics Abstract Purpose of review Many autoimmune rheumatic autoimmune disorders predominantly affect women. Sex hormones, in particular estrogen, can influence CD4+ T-helper development and function. We highlight recent studies that begin to provide insights into the mechanisms by which estrogen modulates CD4+ T-cell development and function, and thus potentially contribute to disease pathogenesis. Recent findings High levels of estrogen can lead to thymic atrophy. Recent studies showed that this phenomenon results from effects of estrogen at multiple stages in early T-cell development. Estrogen is also known to affect mature CD4+ T-cell function, and, in particular, their ability to produce selected cytokine profiles. The mechanisms by which estrogen can exert these effects were also recently explored and shown to include effects on expression of critical molecules known to be involved in these processes. Summary Dissecting the molecular pathways employed by estrogen to modulate CD4+ T cells will be critical in elucidating the manner by which estrogen exerts its effects on this compartment. Given that cell type specific differences underlie the ability of many hormonal therapies to exert tissue-specific estrogenic or antiestrogenic activities, this knowledge will be crucial to further exploitation of hormonal therapies in rheumatic autoimmune diseases. © 2007 Lippincott Williams & Wilkins, Inc.