Purpose of review Stenotrophomonas maltophilia
can cause persistent airway colonization and chronic infection in cystic fibrosis
(CF) patients. The clinical effect of chronic S. maltophilia
infection is still a matter of debate. The purpose of the review is to summarize studies published during the last 1.5 years with a focus on whether S. maltophilia
should be regarded as a ‘true’ CF pathogen.
Studies concerning the microbiological characteristics of this microorganism with special focus on identification, virulence factors, cross-infection and resistance pattern, and studies on clinical effects of chronic infection, specifically serological responses to this infection, negative effects on the clinical status and possible effects of antibiotic treatment have been reviewed.
Summary S. maltophilia
can be identified with certainty, has well-described virulence factors, is capable of cross-infection and often shows multiresistance. Although CF patients with chronic S. maltophilia
infection have lower lung function parameters compared with other CF patients and experience more exacerbations, chronic S. maltophilia
infection in itself was not associated with a worse clinical outcome
. True, pathogenic effects of S. maltophilia
could not be found, but the presence of chronic S. maltophilia
could be a marker of more pronounced lung disease in affected patients.