ASTHMA: Edited by Zuzana Diamant and Nicola A. HananiaManaging chronic rhinosinusitis in severe asthmaRamaswamy, Uma S.; Patel, Vijay A.; Lee, Stella E.Author Information Division of Sino-nasal Disorders and Allergy, Department of Otolaryngology—Head & Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA Correspondence to Stella E. Lee, MD, Division of Sino-nasal Disorders and Allergy, Department of Otolaryngology—Head & Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15219, USA. Tel: +1 412 647 2100/+1 412 232 8989; e-mail: [email protected] Current Opinion in Pulmonary Medicine: January 2021 - Volume 27 - Issue 1 - p 23-28 doi: 10.1097/MCP.0000000000000741 Buy Metrics Abstract Purpose of review Over half of all patients with severe asthma have chronic rhinosinusitis (CRS). Although distinct and specialized in function and form, the upper and lower airways share similar and inter-related pathophysiologic mechanisms. The severity of CRS particularly in patients with nasal polyps can correlate with that of asthma and vice versa. The purpose of this review is to elucidate the relationship between these conditions and summarize key elements in the management of these patients. Recent findings Several advances have been made in the evaluation and treatment of patients with CRS and asthma. Further understanding of inflammatory endotypes common to both CRS and severe asthma hopefully will provide appropriate and effective treatments and improve patient outcomes. Summary CRS significantly impairs quality of life, and therapies are targeted toward improving patient symptoms, and hopefully in the future, treating the underlying immune dysfunction. Management of CRS and severe asthma requires a multidisciplinary approach. Further real-world studies are necessary to determine the best treatment algorithm for these patients. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.