ASTHMA: Edited by Zuzana Diamant and Nicola A. HananiaAllergen bronchoprovocation test: an important research tool supporting precision medicineBoulet, Louis-Philippea; Côté, Andréannea; Abd-Elaziz, Khalidb; Gauvreau, Gailc; Diamant, Zuzanad,e,fAuthor Information aInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Québec Heart and Lung Institute, Université Laval, Québec, Canada bQPS-Netherlands, Groningen, The Netherlands cDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada dDepartment of Respiratory Medicine and Allergology, Institute for Clinical Science, Skane University Hospital, Lund University, Lund, Sweden eDepartment of Respiratory Medicine, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic fDepartment Clinical Pharmacy and Pharmacology, University Groningen, University Medicine Ctr Groningen, Groningen, The Netherlands Correspondence to Louis-Philippe Boulet, MD, FRCPC, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval (IUCPQ-UL), 2725, Chemin Sainte-Foy, QC, Canada G1V 4G5. Tel: +1 418 656 4747; fax: +1 418 656 4762; e-mail: [email protected] Current Opinion in Pulmonary Medicine: January 2021 - Volume 27 - Issue 1 - p 15-22 doi: 10.1097/MCP.0000000000000742 Buy Metrics Abstract Purpose of review Allergen bronchoprovocation test (ABT) has been used to study asthma pathophysiology and as a disease-modelling tool to assess the properties and efficacy of new asthma drugs. In view of the complexity and heterogeneity of asthma, which has driven the definition of several phenotypes and endotypes, we aim to discuss the role of ABT in the era of precision medicine and provide guidance for clinicians how to interpret and use available data to understand the implications for the benefits of asthma treatment. Recent findings In this review, we summarize background knowledge and applications of ABT and provide an update with recent publications on this topic. In the past years, several studies have been published on ABT in combination with non-invasive and invasive airway samplings and innovative detection techniques allowing to study several inflammatory mechanisms linked to Th2-pathway and allergen-induced pathophysiology throughout the airways. Summary ABT is a valuable research tool, which has strongly contributed to precision medicine by helping to define allergen-triggered key inflammatory pathways and airway pathophysiology, and thus helped to shape our understanding of allergen-driven asthma phenotypes and endotypes. In addition, ABT has been instrumental to assess the interactions and effects of new-targeted asthma treatments along these pathways. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.