DISEASES OF THE PLEURA: Edited by Richard LightAdvances in pathological diagnosis of mesothelioma what pulmonologists should knowLouw, Ambera,b; Badiei, Arashc; Creaney, Jenetted; Chai, Ming S.a; Lee, Y.C. Garyc,d,e Author Information aPathWest Laboratory Medicine, QEII Medical Centre bSchool of Medical and Health Sciences, Edith Cowan University cDepartment of Respiratory Medicine, Sir Charles Gairdner Hospital dNational Centre for Asbestos Related Diseases & University of Western Australia eCentre for Respiratory Health, University of Western Australia, Perth, Western Australia, Australia Correspondence to Y.C. Gary Lee, School of Medicine, UWA, 533 Harry Perkins Bldg, QE II Med Ctr, Perth 6009, WA, Australia. Tel: +61 8 61510913; fax: +61 8 64572816; e-mail: [email protected] Current Opinion in Pulmonary Medicine: July 2019 - Volume 25 - Issue 4 - p 354-361 doi: 10.1097/MCP.0000000000000578 Buy Metrics Abstract Purpose of review Malignant pleural mesothelioma (MPM) is a universally fatal illness with a rising incidence, particularly in developing countries. The diagnosis can be challenging and require repeated investigations with implications for the patient and healthcare system. Recent findings Distinguishing between benign/reactive and malignant mesothelial proliferations can be challenging. Cytological diagnosis of MPM from pleural fluid is as reliable as histological analysis of tissue biopsies in epithelioid MPM – an approach endorsed by the International Academy of Cytology. Identification of BRCA1-associated protein 1 (BAP1) and cyclin-dependent kinase inhibitor 2A (CDKN2A) gene mutations in MPM have led to the development of new ancillary tests that can streamline the diagnostic pathway. The prognostic values of these molecules are being investigated. Clinicians should be aware of the recently described BAP1 tumor predisposition syndrome and offer genetic investigations in potential patients. Routine use of prophylactic radiotherapy in MPM patients after pleural interventions has been disproved in a randomized trial. Summary Diagnosis of epithelioid MPM can be established on pleural fluid analysis in most patients. The use of BAP1 immunostaining and CDKN2A/p16 fluorescence in-situ hybridization are particularly useful in distinguishing benign from malignant mesothelial proliferations. Clinicians should ensure these investigations are available in the pathological assessment of cases to minimize invasive investigations and the associated risks. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.