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Chronic obstructive pulmonary disease and bronchiectasis

Novosad, Shannon A.; Barker, Alan F.

Current Opinion in Pulmonary Medicine: March 2013 - Volume 19 - Issue 2 - p 133–139
doi: 10.1097/MCP.0b013e32835d8312
OBSTRUCTIVE, OCCUPATIONAL AND ENVIRONMENTAL DISEASES: Edited by Basil Varkey
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Purpose of review Chronic obstructive pulmonary disease (COPD) and bronchiectasis are two different but related diseases that occur separately, but can coexist. In this review, we will examine the recent research regarding patients with COPD who have coexisting bronchiectasis.

Recent findings Recent research has focused on defining distinct COPD phenotypes with the ultimate goal of changing the outcomes using tailored therapies. A frequent exacerbator phenotype has been identified. COPD patients with Pseudomonas aeruginosa are a phenotype with worse outcomes. Patients with coexisting COPD and bronchiectasis may represent a unique phenotype.

Summary Patients with coexisting COPD and bronchiectasis could represent a unique phenotype with more severe disease, worse outcomes, more isolation of potentially pathogenic microorganisms, and more frequent exacerbations, with the potential for targeted therapies.

Pulmonary and Critical Care, Oregon Health and Science University, Portland, Oregon, USA

Correspondence to Alan F. Barker, Pulmonary and Critical Care, UHN-67, OHSU, Portland, OR 97239, USA. Tel: +1 503 494 7680; e-mail: barkera@ohsu.edu

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins