Diseases of the pleura: Edited by Richard W. LightMesothelioma due to environmental exposure to erionite in TurkeyDikensoy, OnerAuthor Information Department of Pulmonary Diseases, Gaziantep University, Gaziantep, Turkey Correspondence to Oner Dikensoy, MD, Department of Pulmonary Diseases, Gaziantep University, Gaziantep 27310, Turkey Tel: +90 342 3606060 (ext. 76187); fax: +90 342 3606306; e-mail: [email protected] Current Opinion in Pulmonary Medicine: July 2008 - Volume 14 - Issue 4 - p 322-325 doi: 10.1097/MCP.0b013e3282fcea65 Buy Metrics Abstract Purpose of review The prevalence of malignant mesothelioma due to erionite exposure in Central Anatolia is very high. In this report, we review the recent developments on this epidemic on the basis of previous literature. Recent findings Recently, it has been shown that erionite is poorly cytotoxic, induces proliferating signals and high growth rate in human mesothelial cells. Additionally, long-term exposure to erionite transforms human mesothelial cells in vitro, regardless of the presence of Simian Virus 40 sequences, leading to foci formation in cultured monolayers. It has also been confirmed that a genetic predisposition to erionite carcinogenesis is the cause of the mesothelioma epidemic in Cappadocia. Summary The data obtained recently on the epidemiology, etiology, and pathogenesis of the mesothelioma due to erionite exposure in Turkey are described. © 2008 Lippincott Williams & Wilkins, Inc.