Infectious diseases: Edited by Alimuddin ZumlaRecent antiviral strategies against human coronavirus-related respiratory illnessesGolda, Anna; Pyrc, Krzysztof Author Information Microbiology Department, Faculty of Biochemistry Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland Correspondence to Krzysztof Pyrc, Microbiology Department, Faculty of Biochemistry Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland Tel: +48 12 664 63 78; fax: +48 12 664 69 02; e-mail: [email protected] Current Opinion in Pulmonary Medicine: May 2008 - Volume 14 - Issue 3 - p 248-253 doi: 10.1097/MCP.0b013e3282f7646f Buy Metrics Abstract Purpose of review The main purpose of this review is to summarize the current research (2006–2007) concerning the development of novel anticoronaviral strategies and compounds. Recent findings Recent research led to the identification of several novel agents inhibiting coronaviral replication. The most promising compounds include carbohydrate-binding agents, neutralizing antibodies and drugs targeting a coronaviral envelope protein. Summary Although initial outbreaks of coronavirus that causes severe acute respiratory syndrome (SARS-CoV) were controlled by public health measures, the development of vaccines and antiviral agents for SARS-CoV is essential for improving control and treatment of future outbreaks. Four years after the SARS-CoV epidemic, several compounds with an anticoronaviral activity have been identified. © 2008 Lippincott Williams & Wilkins, Inc.