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Psychosis in neurodegenerative disorders

recent developments

Karameh, Wael K.a,b,c; Murari, Geetanjalia; Schweizer, Tom A.a,d,e,f,g; Munoz, David G.a,h,i; Fischer, Corinne E.a,b,d

Current Opinion in Psychiatry: March 2019 - Volume 32 - Issue 2 - p 117–122
doi: 10.1097/YCO.0000000000000476
NEUROCOGNITIVE DISORDERS: Edited by Perminder S. Sachdev and Michael Valenzuela

Purpose of review This review presents the latest developments covered in the literature regarding psychosis in neurodegenerative disorders and discusses possible future research directions.

Recent findings Recent findings in the field of psychosis and neurodegenerative disorders revolve around four main themes. The first theme is the impact of sex on the expression of psychosis in neurodegenerative disorders. The second theme focuses on the relationship between psychosis and neurodegenerative disease biomarkers. The third concerns how psychotic symptoms in neurodegenerative disorders may share common mechanisms with other primary psychotic disorders such as schizophrenia. Finally, there have been some promising developments in the area of therapeutics to treat dementia-related psychosis involving both established and novel treatments.

Summary New findings in the field of neurodegeneration and psychosis parallel new directions in the field of neurodegeneration in general. More specifically, we have seen a shift in focus to issues highlighting the role of sex, biomarkers, translation to other disorders, and therapeutics.

aKeenan Research Centre for Biomedical Research, Li Ka Shing Knowledge Institute, St. Michael's Hospital

bFaculty of Medicine, Division of Geriatric Psychiatry, Department of Psychiatry, University of Toronto

cCentre for Addiction and Mental Health

dInstitute of Medical Sciences

eInstitute of Biomaterials and Biomedical Engineering

fFaculty of Medicine, Division of Neurosurgery, Department of Surgery, University of Toronto

gDivision of Neurosurgery, St. Michael's Hospital

hDepartment of Laboratory Medicine and Pathobiology, University of Toronto

iDivision of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada

Correspondence to Corinne E. Fischer, MD, Keenan Research Centre for Biomedical Research, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON M5B 1T8, Canada. Tel: +416 864 5320; fax: +416 864 5480; e-mail:

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