Secondary Logo

Institutional members access full text with Ovid®

Share this article on:

Exploring the bi-directional relationship between sleep and beta-amyloid

Brown, Belinda M.; Rainey-Smith, Stephanie R.; Bucks, Romola S.; Weinborn, Michael; Martins, Ralph N.

doi: 10.1097/YCO.0000000000000285
SLEEP DISORDERS: Edited by Martica Hall

Purpose of review Suboptimal sleep has been reported as both a comorbidity and risk factor for the development of Alzheimer's disease. Previous research suggests that beta-amyloid (Aβ) may be central to this association, with reports indicating a bi-directional relationship between sleep and Aβ. Here, we review recent animal and human studies investigating the relationship between sleep and measures of Aβ, and explore the potential mechanisms underlying this association.

Recent findings Two recent animal studies have provided further support for a bi-directional relationship between sleep and Aβ. In addition, five recent human studies support the notion that higher brain Aβ is linked to poor sleep in cognitively healthy individuals. One of the recent human studies utilized polysomnography to link brain Aβ to a disruption in slow wave activity during sleep, which in turn was associated with decreased hippocampal-dependent memory.

Summary Recent findings indicate that poor sleep is a risk factor for brain Aβ deposition, and Aβ deposition contributes to sleep disruption. Through the conduct of more mechanistic studies, and both longitudinal and intervention human studies, we can further elucidate the clearly complex nature of the relationship between sleep and Aβ.

aSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia

bSir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Nedlands, Western Australia, Australia

cSchool of Psychology, University of Western Australia, Nedlands, Western Australia, Australia

Correspondence to Belinda M. Brown, Building 11, Hollywood Private Hospital, 115 Monash Avenue, Nedlands, WA 6009, Australia. Tel: +61 8 6298 6314; e-mail:

Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.