Clinical therapeutics: Edited by Dieter Naber and Harold PincusAddressing cardiometabolic risk during treatment with antipsychotic medicationsAmiel, Jonathan Ma,b; Mangurian, Christina Va,b; Ganguli, Rohanc,d; Newcomer, John We Author Information aColumbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, New York, USA bDepartment of Psychiatry, Columbia University College of Physicians and Surgeons in New York, New York, USA cWestern Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA dCenter for Addiction and Mental Health, University of Toronto in Toronto, ON, USA eWashington University School of Medicine, St. Louis, Missouri, USA Correspondence to Jonathan M. Amiel, MD, 1051 Riverside Drive, Box 94, New York, NY 10032, USA Tel: +1 212 543 5553; e-mail: [email protected] Current Opinion in Psychiatry: November 2008 - Volume 21 - Issue 6 - p 613-618 doi: 10.1097/YCO.0b013e328314b74b Buy Metrics Abstract Purpose of review To raise awareness of and inform evidence-based practice regarding medical and behavioral interventions for antipsychotic medication-induced metabolic abnormalities. Recent findings The current literature indicates that individuals with severe and persistent mental illness have significantly worse health outcomes and premature mortality than the general population, owing to a combination of under-recognition and treatment of medical risk factors, reduced access to care, sedentary lifestyle and poor diet, and the potential contribution of adverse metabolic side effects of antipsychotic medications such as weight gain, hyperglycemia and dyslipidemia. A combination of administrative, behavioral and medical approaches to addressing these medical risks may be more effective than any one of these approaches alone. Summary Treatment with antipsychotic medications can induce significant weight gain and abnormalities in lipid and glucose metabolism that increase risk for cardiovascular disease and diabetes in a population already at risk from multiple other sources. Managing the side effects of antipsychotics and lowering risk in general is an important aspect of the management of chronic mental illness. There are a variety of effective medical and behavioral interventions that can be employed to achieve primary and secondary prevention aims. © 2008 Lippincott Williams & Wilkins, Inc.