SchizophreniaSchizophrenia and bipolar disorder: differences and overlapsMaier, Wolfgang; Zobel, Astrid; Wagner, Michael Author Information Department of Psychiatry, University of Bonn, Bonn, Germany Correspondence to Professor Dr Wolfgang Maier, Department of Psychiatry, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany Tel: +49 228 287 5723; fax: +49 228 287 6097; e-mail: [email protected] Current Opinion in Psychiatry: March 2006 - Volume 19 - Issue 2 - p 165-170 doi: 10.1097/01.yco.0000214342.52249.82 Buy Metrics Abstract Purpose of review Following the recent progress mainly in the fields of genetics and neurobiology, the validity of the diagnostic distinction between schizophrenia and bipolar disorder is increasingly challenged. Recent findings Evidence for basic neurobiological processes common for both disorders is expanding with regard to (a) susceptibility genes, (b) neurodevelopment (for example myelination), and (c) brain functions (for example sensory gating, visuospatial achievement). Recent epidemiological studies also stress communalities. Summary The diagnostic split between schizophrenia and bipolar disorder is unable to define distinct etiological and/or pathophysiological entities. © 2006 Lippincott Williams & Wilkins, Inc.