Two advances have been achieved in molecular genetic approches to schizophrenia.The first is progress in the search for linkage across all the human chromosomes. The second advance is the discovery of a new kind of DNA mutation, unstable trinucleotide repeats, that is responsible for several neuropsychiatric disorders. Significant evidence suggests that these unstable genes may also be related to psychotic diseases such as schizophrenia. A number of candidate loci, including neurodevelopmental genes, have been tested and several regions appear promising.
Section of Neurogenetics, Clarke Institute of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Current Opinion in Psychiatry 1995, 8:25-28.
Tsukasa Sasaki and James L. Kennedy, Section of Neurogenetics, Clarke Institute of Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario M5T 1R8, Canada.