ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by Jordan S. OrangeThe effect of coronavirus disease 2019 on newbornsKyle, Margaret H.a,b; Dumitriu, Dania,b,c Author Information aDepartment of Pediatrics bDepartment of Psychiatry cNurture Science Program, Columbia University Irving Medical Center, New York, New York, USA Correspondence to Dani Dumitriu, MD, PhD, New York State Psychiatric Institute, Columbia University Irving Medical Center, 1051 Riverside Drive, Suite 4807, New York, NY 10032, USA. E-mail: [email protected] Current Opinion in Pediatrics: December 2021 - Volume 33 - Issue 6 - p 618-624 doi: 10.1097/MOP.0000000000001063 Buy Metrics Abstract Purpose of review To evaluate the available literature regarding effects of coronavirus disease 2019 (COVID-19) on newborns, ranging from effects related to in utero and perinatal exposure to maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, to pandemic-related stress and socioeconomic changes. Recent findings Several large studies and national registries have shown that the risk of vertical transmission from SARS-CoV-2-infected mothers to newborns is rare and does not appear to be related to postnatal care policies such as mother–newborn separation and breastfeeding. Newborns exposed to SARS-CoV-2 in utero are at higher risk for preterm delivery for reasons still under investigation. When newborns do acquire SARS-CoV-2 infection, their disease course is usually mild. Long-term follow-up data are lacking, but preliminary reports indicate that, similarly to prior natural disasters, being born during the pandemic may be associated with developmental risk. Summary Although risk of vertical or perinatal transmission is low across a range of postnatal care practices, early indicators suggest developmental risk to the generation born during the pandemic. Long-term follow-up data are critically needed to determine the developmental impact of in utero and early life exposure to SARS-CoV-2 and the COVID-19 pandemic. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.