OFFICE PEDIATRICS: Edited by Henry H. BernsteinCutaneous coronavirus disease 2019 in children: a clinical primer for diagnosis and treatmentDinulos, James Ellisa; Dinulos, James Garyb,c,d Author Information aDartmouth College, 2020 bSeacoast Dermatology, PLLC, Portsmouth cDepartment of Dermatology, Geisel School of Medicine at Dartmouth, Hanover New Hampshire dDepartment of Dermatology, University of Connecticut School of Medicine, Framingham, Connecticut, USA Correspondence to James Gary Dinulos, MD, Seacoast Dermatology, PLLC, 330 Borthwick Avenue, Suite 303, Portsmouth, New Hampshire, USA. Tel: +1 603 431 5205; fax: +1 603 436 4257; e-mail: [email protected] Current Opinion in Pediatrics: December 2021 - Volume 33 - Issue 6 - p 691-703 doi: 10.1097/MOP.0000000000001076 Buy Metrics Abstract Purpose of review This review examines the global literature regarding rashes encountered in children and adults infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and aims to provide practicing pediatricians with an understanding of the relationship between instances of rashes and coronavirus disease 2019 (COVID-19) in children in order to effectively evaluate and treat patients. Recent findings The true incidence of cutaneous reactions in children infected with SARS-CoV-2 is not known. Children's immune systems differ from those of adults and rashes as a manifestation of immune responses, in turn, differ in morphology and distribution. Rarely, children develop a severe multisystem inflammatory syndrome that has overlapping clinical features with Kawasaki disease. In addition, vaccinations produce rashes similar to natural infections. The rashes associated with COVID-19 vaccination are mild and transient, and should not preclude vaccination. Lastly, children who chronically wear masks are more likely to experience flaring of acne around the nose and mouth (’maskne’) and facial conditions such as seborrheic dermatitis. Summary There are ongoing worldwide registries, clinical and basic science studies to better understand the burden of skin disease and pathophysiology of rashes seen in patients infected with COVID-19. Robust vaccination programs should be encouraged as a way to contain viral spread among children and the greater population. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.