GASTROENTEROLOGY AND NUTRITION: Edited by Bradley BarthPancreatic complications in children with cystic fibrosisSellers, Zachary M. Author Information Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University, Stanford, California, USA Correspondence to Zachary M. Sellers, MD, PhD, 750 Welch Road, Suite 116, Palo Alto, CA 94304, USA. Tel: +1 650 723 5070; e-mail: [email protected] Current Opinion in Pediatrics: October 2020 - Volume 32 - Issue 5 - p 661-667 doi: 10.1097/MOP.0000000000000934 Buy Metrics Abstract Purpose of review The pancreas is highly affected in cystic fibrosis, with complications occurring early in childhood. This review highlights recent research in exocrine pancreatic function in the era of cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies and discusses how these are affecting pancreatitis and exocrine pancreatic insufficiency (EPI) in children. Additionally, new research into exocrine--endocrine interactions sheds light on how CFTR dysfunction in ductal cells may affect beta cells. Recent findings Ivacaftor has disproved the hypothesis that EPI in children with cystic fibrosis is irreversible. Improvements in pancreatic function have increased pancreatitis episodes in some children and reduced them in others. Imaging advances are providing complementary methods for exocrine pancreatic function testing. New research into the interplay between the exocrine and endocrine components of the pancreas are elucidating the intertwined and complex relationship between the exocrine and endocrine pancreas. Summary Pancreatic complications contribute to the morbidity and mortality of children with cystic fibrosis. Increasing use of highly effective CFTR modulators will not only abrogate these but will also advance our understanding of pancreatic pathophysiology in cystic fibrosis. New frontiers into pancreatic gene therapy and exocrine--endocrine research will help provide new therapeutic opportunities for pancreatitis, EPI, and diabetes in cystic fibrosis. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.